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Independent Predict...
Independent Predictors of Cardiac Mortality and Hospitalization for Heart Failure in a Multi-Ethnic Asian ST-segment Elevation Myocardial Infarction Population Treated by Primary Percutaneous Coronary Intervention
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Bulluck, H (author)
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Zheng, HL (author)
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Chan, MY (author)
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Foin, N (author)
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Foo, DC (author)
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Lee, CW (author)
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Lim, ST (author)
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- Sahlen, A (author)
- Karolinska Institutet
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Tan, HC (author)
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Tan, JW (author)
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Tong, KL (author)
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Wong, AS (author)
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Wong, PE (author)
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Yeo, KK (author)
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Foo, LL (author)
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Chua, TS (author)
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Koh, TH (author)
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Hausenloy, DJ (author)
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(creator_code:org_t)
- 2019-07-11
- 2019
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 10072-
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
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- We aimed to identify independent predictors of cardiac mortality and hospitalization for heart failure (HHF) from a real-world, multi-ethnic Asian registry [the Singapore Myocardial Infarction Registry] of ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention. 11,546 eligible STEMI patients between 2008 and 2015 were identified. In-hospital, 30-day and 1-year cardiac mortality and 1-year HHF rates were 6.4%, 6.8%, 8.3% and 5.2%, respectively. From the derivation cohort (70% of patients), age, Killip class and cardiac arrest, creatinine, hemoglobin and troponin on admission and left ventricular ejection fraction (LVEF) during hospitalization were predictors of in-hospital, 30-day and 1-year cardiac mortality. Previous ischemic heart disease (IHD) was a predictor of in-hospital and 30-day cardiac mortality only, whereas diabetes was a predictor of 1-year cardiac mortality only. Age, previous IHD and diabetes, Killip class, creatinine, hemoglobin and troponin on admission, symptom-to-balloon-time and LVEF were predictors of 1-year HHF. The c-statistics were 0.921, 0.901, 0.881, 0.869, respectively. Applying these models to the validation cohort (30% of patients) showed good fit and discrimination (c-statistic 0.922, 0.913, 0.903 and 0.855 respectively; misclassification rate 14.0%, 14.7%, 16.2% and 24.0% respectively). These predictors could be incorporated into specific risk scores to stratify reperfused STEMI patients by their risk level for targeted intervention.
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- By the author/editor
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Bulluck, H
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Zheng, HL
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Chan, MY
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Foin, N
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Foo, DC
-
Lee, CW
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show more...
-
Lim, ST
-
Sahlen, A
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Tan, HC
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Tan, JW
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Tong, KL
-
Wong, AS
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Wong, PE
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Yeo, KK
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Foo, LL
-
Chua, TS
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Koh, TH
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Hausenloy, DJ
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show less...
- Articles in the publication
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Scientific repor ...
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Karolinska Institutet