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Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia
- Banning, LCP (author)
- Janssen, EPCJ (author)
- Hamel, REG (author)
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- de Vugt, M (author)
- Kohler, S (author)
- Wolfs, CAG (author)
- Oosterveld, SM (author)
- Melis, RJF (author)
- Rikkert, MGMO (author)
- Kessels, RPC (author)
- Pijnenburg, YAL (author)
- Koene, T (author)
- van der Flier, WM (author)
- Scheltens, P (author)
- Verhey, FRJ (author)
- Aalten, P (author)
- Ramakers, IHGB (author)
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- (creator_code:org_t)
- 2019-10-23
- 2020
- English.
- In: Journal of geriatric psychiatry and neurology. - : SAGE Publications. - 0891-9887 .- 1552-5708. ; 33:5, s. 256-264
- Journal article (peer-reviewed)
Abstract
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- To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
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- Banning, LCP
- Janssen, EPCJ
- Hamel, REG
- de Vugt, M
- Kohler, S
- Wolfs, CAG
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- Oosterveld, SM
- Melis, RJF
- Rikkert, MGMO
- Kessels, RPC
- Pijnenburg, YAL
- Koene, T
- van der Flier, W ...
- Scheltens, P
- Visser, PJ
- Verhey, FRJ
- Aalten, P
- Ramakers, IHGB
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- Journal of geria ...
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- Karolinska Institutet
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