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Determinants of Cro...
Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia
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Banning, LCP (author)
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Janssen, EPCJ (author)
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Hamel, REG (author)
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de Vugt, M (author)
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Kohler, S (author)
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Wolfs, CAG (author)
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Oosterveld, SM (author)
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Melis, RJF (author)
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Rikkert, MGMO (author)
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Kessels, RPC (author)
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Pijnenburg, YAL (author)
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Koene, T (author)
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van der Flier, WM (author)
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Scheltens, P (author)
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- Visser, PJ (author)
- Karolinska Institutet
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Verhey, FRJ (author)
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Aalten, P (author)
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Ramakers, IHGB (author)
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(creator_code:org_t)
- 2019-10-23
- 2020
- English.
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In: Journal of geriatric psychiatry and neurology. - : SAGE Publications. - 0891-9887 .- 1552-5708. ; 33:5, s. 256-264
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https://doi.org/10.1...
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Abstract
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- To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Banning, LCP
-
Janssen, EPCJ
-
Hamel, REG
-
de Vugt, M
-
Kohler, S
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Wolfs, CAG
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show more...
-
Oosterveld, SM
-
Melis, RJF
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Rikkert, MGMO
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Kessels, RPC
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Pijnenburg, YAL
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Koene, T
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van der Flier, W ...
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Scheltens, P
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Visser, PJ
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Verhey, FRJ
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Aalten, P
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Ramakers, IHGB
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show less...
- Articles in the publication
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Journal of geria ...
- By the university
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Karolinska Institutet