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Skin T cells mainta...
Skin T cells maintain their diversity and functionality in the elderly
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- Koguchi-Yoshioka, H (author)
- Karolinska Institutet
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- Hoffer, E (author)
- Karolinska Institutet
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Cheuk, S (author)
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Matsumura, Y (author)
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Vo, S (author)
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Kjellman, P (author)
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Grema, L (author)
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Ishitsuka, Y (author)
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Nakamura, Y (author)
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Okiyama, N (author)
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Fujisawa, Y (author)
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Fujimoto, M (author)
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- Eidsmo, L (author)
- Karolinska Institutet
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Clark, RA (author)
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Watanabe, R (author)
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(creator_code:org_t)
- 2021-01-04
- 2021
- English.
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In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 13-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people.
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- By the author/editor
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Koguchi-Yoshioka ...
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Hoffer, E
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Cheuk, S
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Matsumura, Y
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Vo, S
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Kjellman, P
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show more...
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Grema, L
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Ishitsuka, Y
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Nakamura, Y
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Okiyama, N
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Fujisawa, Y
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Fujimoto, M
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Eidsmo, L
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Clark, RA
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Watanabe, R
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show less...
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Communications b ...
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Karolinska Institutet