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1H, 13C and 15N che...
1H, 13C and 15N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2
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Schnieders, R (author)
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Peter, SA (author)
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Banijamali, E (author)
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Riad, M (author)
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Altincekic, N (author)
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Bains, JK (author)
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Ceylan, B (author)
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Furtig, B (author)
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Grun, JT (author)
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Hengesbach, M (author)
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Hohmann, KF (author)
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Hymon, D (author)
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Knezic, B (author)
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Oxenfarth, A (author)
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- Petzold, K (author)
- Karolinska Institutet
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Qureshi, NS (author)
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Richter, C (author)
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Schlagnitweit, J (author)
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Schlundt, A (author)
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Schwalbe, H (author)
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Stirnal, E (author)
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Sudakov, A (author)
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Vogele, J (author)
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Wacker, A (author)
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Weigand, JE (author)
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Wirmer-Bartoschek, J (author)
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Wohnert, J (author)
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(creator_code:org_t)
- 2021-01-23
- 2021
- English.
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In: Biomolecular NMR assignments. - : Springer Science and Business Media LLC. - 1874-270X .- 1874-2718. ; 15:1, s. 203-211
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a positive sense single-stranded RNA genome and belongs to the genus of Betacoronaviruses. The 5′- and 3′-genomic ends of the 30 kb SCoV-2 genome are potential antiviral drug targets. Major parts of these sequences are highly conserved among Betacoronaviruses and contain cis-acting RNA elements that affect RNA translation and replication. The 31 nucleotide (nt) long highly conserved stem-loop 5a (SL5a) is located within the 5′-untranslated region (5′-UTR) important for viral replication. SL5a features a U-rich asymmetric bulge and is capped with a 5′-UUUCGU-3′ hexaloop, which is also found in stem-loop 5b (SL5b). We herein report the extensive 1H, 13C and 15N resonance assignment of SL5a as basis for in-depth structural studies by solution NMR spectroscopy.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Schnieders, R
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Peter, SA
-
Banijamali, E
-
Riad, M
-
Altincekic, N
-
Bains, JK
-
show more...
-
Ceylan, B
-
Furtig, B
-
Grun, JT
-
Hengesbach, M
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Hohmann, KF
-
Hymon, D
-
Knezic, B
-
Oxenfarth, A
-
Petzold, K
-
Qureshi, NS
-
Richter, C
-
Schlagnitweit, J
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Schlundt, A
-
Schwalbe, H
-
Stirnal, E
-
Sudakov, A
-
Vogele, J
-
Wacker, A
-
Weigand, JE
-
Wirmer-Bartosche ...
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Wohnert, J
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show less...
- Articles in the publication
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Biomolecular NMR ...
- By the university
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Karolinska Institutet