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Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?

Soderberg-Naucler, C (author)
Karolinska Institutet
 (creator_code:org_t)
2021-03-12
2021
English.
In: Immunity & ageing : I & A. - : Springer Science and Business Media LLC. - 1742-4933. ; 18:1, s. 12-
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  • The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?

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