Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5)

Bergstrom, A (author)

Rozell, B (author)

(creator_code:org_t)

2021-06-11
2021
English.
In: Transgenic research. - : Springer Science and Business Media LLC. - 1573-9368 .- 0962-8819. ; 30:5, s. 701-707

Related links:: https://link.springe...; show more...; http://kipublication...; https://doi.org/10.1...; show less...

Abstract Subject headings

Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited primarily due to a paucity of model systems mirroring the disease. Here, we describe the Keratin 5 (K5)-Cre; Klf5fl/fl mouse that spontaneously develops severe liver disease during the postnatal period with features resembling PSC including a prominent ductular reaction, fibrotic obliteration of the bile ducts and secondary degeneration/necrosis of liver parenchyma. Over time, there is an expansion of Sox9+ hepatocytes in the damaged livers suggestive of a hepatocyte-mediated regenerative response. We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre; Klf5fl/fl mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver.

By the author/editor: Bergstrom, A; Gerling, M; Van Hul, N; Moro, CF; Rozell, B; Toftgard, R; show more...; Sur, I; show less...

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