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Tumor-Associated Trypsin Inhibitor (TATI) as a Biomarker of Poor Prognosis in Oropharyngeal Squamous Cell Carcinoma Irrespective of HPV Status
- Sjoblom, A (author)
- Stenman, UH (author)
- Hagstrom, J (author)
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- Jouhi, L (author)
- Haglund, C (author)
- Syrjanen, S (author)
- Mattila, P (author)
- Carpen, T (author)
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- (creator_code:org_t)
- 2021-06-04
- 2021
- English.
- In: Cancers. - : MDPI AG. - 2072-6694. ; 13:11
- Journal article (peer-reviewed)
Abstract
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- Background: We studied the role of tumor-associated trypsin inhibitor (TATI) in serum and in tumor tissues among human papillomavirus (HPV)-positive and HPV-negative OPSCC patients. Materials and methods: The study cohort included 90 OPSCC patients treated at the Helsinki University Hospital (HUS), Helsinki, Finland, in 2012–2016. TATI serum concentrations (S-TATIs) were determined by an immunofluorometric assay. Immunostaining was used to assess tissue expression. HPV status was determined with a combination of p16 immunohistochemistry and HPV DNA PCR genotyping. The survival endpoints were overall survival (OS) and disease-specific survival (DSS). Results: A significant correlation was found between S-TATI positivity and poor OS (p < 0.001) and DSS (p = 0.04) in all patients. In HPV-negative cases, S-TATI positivity was linked to poor OS (p = 0.01) and DSS (p = 0.05). In HPV-positive disease, S-TATI positivity correlated with poor DSS (p = 0.01). S-TATI positivity was strongly associated with HPV negativity. TATI serum was negatively linked to a lower cancer stage. TATI expression in peritumoral lymphocytes was associated with favorable OS (p < 0.025) and HPV positivity. TATI expression in tumor and in peritumoral lymphocytes correlated with lower cancer stages. Conclusion: Our results suggest that S-TATI positivity may be a biomarker of poor prognosis in both HPV-positive and HPV-negative OPSCC.
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- Sjoblom, A
- Stenman, UH
- Hagstrom, J
- Jouhi, L
- Haglund, C
- Syrjanen, S
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- Mattila, P
- Makitie, A
- Carpen, T
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- Cancers
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- Karolinska Institutet
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