id:"swepub:oai:prod.swepub.kib.ki.se:147077644"
Search: id:"swepub:oai:prod.swepub.kib.ki.se:147077644" > Hyperdense artery s...
- 1 of 1
- Previous record
- Next record
- To hitlist
Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke
- Wu, S (author)
- Mair, G (author)
- Cohen, G (author)
- show more...
- Morris, Z (author)
- Bradey, N (author)
- Cala, L (author)
- Peeters, A (author)
- Farrall, AJ (author)
- Adami, A (author)
- Potter, G (author)
- Liu, M (author)
- Lindley, RI (author)
- Sandercock, PAG (author)
- Wardlaw, JM (author)
- show less...
- (creator_code:org_t)
- 2020-11-27
- 2021
- English.
- In: Stroke and vascular neurology. - : BMJ. - 2059-8696 .- 2059-8688. ; 6:2, s. 238-243
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Alteplase improves functional outcomes of patients with acute ischaemic stroke, but its effects on symptomatic infarct swelling, an adverse complication of stroke and the influence of CT hyperdense artery sign (HAS) are unclear. This substudy of the Third International Stroke Trial aimed to investigate the association between HAS and symptomatic infarct swelling and effect of intravenous alteplase on this association.MethodsWe included stroke patients whose prerandomisation scan was non-contrast CT. Raters, masked to clinical information, assessed baseline (prerandomisation) and follow-up (24–48 hours postrandomisation) CT scans for HAS, defined as an intracranial artery appearing denser than contralateral arteries. Symptomatic infarct swelling was defined as clinically significant neurological deterioration ≤7 days after stroke with radiological evidence of midline shift, effacement of basal cisterns or uncal herniation.ResultsAmong 2961 patients, HAS presence at baseline was associated with higher risk of symptomatic infarct swelling (OR 2.21; 95% CI 1.42 to 3.44). Alteplase increased the risk of swelling (OR 1.69; 95% CI 1.11 to 2.57), with no difference between patients with and those without baseline HAS (p=0.49). In patients with baseline HAS, alteplase reduced the proportion with HAS at follow-up (OR 0.67; 95% CI 0.50 to 0.91), where HAS disappearance was associated with reduced risk of swelling (OR 0.25, 95% CI 0.14 to 0.47).ConclusionAlthough alteplase was associated with increased risk of symptomatic infarct swelling in patients with or without baseline HAS, it was also associated with accelerated clearance of HAS, which in return reduced swelling, providing further mechanistic insights to underpin the benefits of alteplase.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Stroke and vascular neurology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Wu, S
- Mair, G
- Cohen, G
- Morris, Z
- Von Heijne, A
- Bradey, N
- show more...
- Cala, L
- Peeters, A
- Farrall, AJ
- Adami, A
- Potter, G
- Liu, M
- Lindley, RI
- Sandercock, PAG
- Wardlaw, JM
- show less...
- Articles in the publication
- Stroke and vascu ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
