Search: id:"swepub:oai:prod.swepub.kib.ki.se:149526899" >
Subtype-Specific Su...
Subtype-Specific Surface Proteins on Adipose Tissue Macrophages and Their Association to Obesity-Induced Insulin Resistance
-
Strand, K (author)
-
Stiglund, N (author)
-
Haugstoyl, ME (author)
-
show more...
-
Kamyab, Z (author)
-
Langhelle, V (author)
-
Dyer, L (author)
-
Busch, C (author)
-
Cornillet, M (author)
-
Hjellestad, ID (author)
-
Nielsen, HJ (author)
-
Njolstad, PR (author)
-
Mellgren, G (author)
-
- Bjorkstrom, NK (author)
- Karolinska Institutet
-
Ferno, J (author)
-
show less...
-
(creator_code:org_t)
- 2022-04-11
- 2022
- English.
-
In: Frontiers in endocrinology. - : Frontiers Media SA. - 1664-2392. ; 13, s. 856530-
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis of metabolic diseases, but a detailed characterization of pro- and anti-inflammatory adipose tissue macrophages (ATMs) in human obesity and how they are distributed in visceral- and subcutaneous adipose depots is lacking. In this study, we performed a surface proteome screening of pro- and anti-inflammatory ATMs in both subcutaneous- (SAT) and visceral adipose tissue (VAT) and evaluated their relationship with systemic insulin resistance. From the proteomics screen we found novel surface proteins specific to M1-like- and M2-like macrophages, and we identified depot-specific immunophenotypes in SAT and VAT. Furthermore, we found that insulin resistance, assessed by HOMA-IR, was positively associated with a relative increase in pro-inflammatory M1-like macrophages in both SAT and VAT.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Strand, K
-
Stiglund, N
-
Haugstoyl, ME
-
Kamyab, Z
-
Langhelle, V
-
Dyer, L
-
show more...
-
Busch, C
-
Cornillet, M
-
Hjellestad, ID
-
Nielsen, HJ
-
Njolstad, PR
-
Mellgren, G
-
Bjorkstrom, NK
-
Ferno, J
-
show less...
- Articles in the publication
-
Frontiers in end ...
- By the university
-
Karolinska Institutet