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Plasma proteins ele...
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
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- Mikus, MS (author)
- Karolinska Institutet,Dept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Dept of Thoracic Medicine, Medical School, University of Crete, Heraklion, Crete, Greece
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- Kolmert, J (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
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- Andersson, LI (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
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- Ostling, J (author)
- Gothenburg, Sweden
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- Knowles, RG (author)
- Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom
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- Gomez, C (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
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- Ericsson, M (author)
- Dept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Thorngren, JO (author)
- Dept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Khoonsari, PE (author)
- Dept of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Solna, Sweden
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- Dahlen, B (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Kupczyk, M (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Internal Medicine, Asthma and Allergy, Medical University of Lodz, University of Lodz, Lodz, Poland
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- De Meulder, B (author)
- European Institute for Systems Biology and Medicine, Lyon, France,Dept of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
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- Auffray, C (author)
- European Institute for Systems Biology and Medicine, Lyon, France
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- Bakke, PS (author)
- Dept of Clinical Science, University of Bergen, Bergen, Norway
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Beghe, B (author)
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- Bel, EH (author)
- Dept of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
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- Caruso, M (author)
- Dept of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
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- Chanez, P (author)
- Assistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France
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- Chawes, B (author)
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
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- Fowler, SJ (author)
- Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester; Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK
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- Gaga, M (author)
- Respiratory Medicine Dept and Asthma Centre, Athens Chest Hospital "Sotiria", University of Athens, Athens, Greece
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- Geiser, T (author)
- Dept for Pulmonary Medicine, University Hospital and University of Bern, Bern, Switzerland
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- Gjomarkaj, M (author)
- Institute for Research and Biomedical Innovation, Italian National Research Council, Palermo, Italy
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- Horvath, I (author)
- Dept of Pulmonology, Semmelweis University, Budapest, Hungary
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- Howarth, PH (author)
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Johnston, SL (author)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- Joos, G (author)
- Dept of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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- Krug, N (author)
- Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
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- Montuschi, P (author)
- Dept of Pharmacology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
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- Musial, J (author)
- Karolinska Institutet
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- Nizankowska-Mogilnicka, E (author)
- Dept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
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- Olsson, HK (author)
- Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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- Papi, A (author)
- Division of lnternal and Cardiorespiratory Medicine, University of Ferrara, Ferrara, Italy
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- Rabe, KF (author)
- Dept of Internal Medicine, Christian Albrechts University Kiel, Kiel, Germany
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- Sandström, Thomas, 1957- (author)
- Umeå universitet,Avdelningen för medicin
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- Shaw, DE (author)
- Karolinska Institutet
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Siafakas, NM (author)
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- Riley, JH (author)
- Respiratory Therapeutic Unit, GlaxoSmithKline, London, United Kingdom
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- Bates, S (author)
- Respiratory Therapeutic Unit, GlaxoSmithKline, London, United Kingdom
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- Middelveld, RJM (author)
- Karolinska Institutet
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- Wheelock, CE (author)
- Karolinska Institutet,Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
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- Chung, KF (author)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- Adcock, IM (author)
- National Heart and Lung Institute, Imperial College London, London, United Kingdom
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- Sterk, PJ (author)
- Dept of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
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- Djukanovic, R (author)
- NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Dahlen, SE (author)
- Karolinska Institutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
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- James, A (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.
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(creator_code:org_t)
- 2021-11-04
- 2022
- English.
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In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 59:2
- Related links:
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https://doi.org/10.1...
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Asthma phenotyping requires novel biomarker discovery.ObjectivesTo identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs).MethodsAn antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED.ResultsIn U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation.ConclusionsThe plasma proteomic panel revealed previously unexplored yet potentially useful Type-2-independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Mikus, MS
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Kolmert, J
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Andersson, LI
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Ostling, J
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Knowles, RG
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Gomez, C
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show more...
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Ericsson, M
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Thorngren, JO
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Khoonsari, PE
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Dahlen, B
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Kupczyk, M
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De Meulder, B
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Auffray, C
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Bakke, PS
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Beghe, B
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Bel, EH
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Caruso, M
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Chanez, P
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Chawes, B
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Fowler, SJ
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Gaga, M
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Geiser, T
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Gjomarkaj, M
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Horvath, I
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Howarth, PH
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Johnston, SL
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Joos, G
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Krug, N
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Montuschi, P
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Musial, J
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Nizankowska-Mogi ...
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Olsson, HK
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Papi, A
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Rabe, KF
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Sandström, Thoma ...
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Shaw, DE
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Siafakas, NM
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Uhlén, Mathias
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Riley, JH
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Bates, S
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Middelveld, RJM
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Wheelock, CE
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Chung, KF
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Adcock, IM
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Sterk, PJ
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Djukanovic, R
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Nilsson, Peter
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Dahlen, SE
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James, A
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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The European res ...
- By the university
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Karolinska Institutet
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Umeå University
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Royal Institute of Technology