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Wild-type Puumala h...
Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques
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- Klingstrom, J (författare)
- Karolinska Institutet
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Plyusnin, A (författare)
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Vaheri, A (författare)
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- Lundkvist, A (författare)
- Karolinska Institutet
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(creator_code:org_t)
- American Society for Microbiology, 2002
- 2002
- Engelska.
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Ingår i: Journal of virology. - : American Society for Microbiology. - 0022-538X .- 1098-5514. ; 76:1, s. 444-449
- Relaterad länk:
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https://jvi.asm.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Hantaviruses cause two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Approximately 200,000 cases are reported annually, and there is to date no specific treatment available. A major obstacle in studying the medical aspects of HFRS and HPS has been the lack of an adequate animal model. Here we show that infection of cynomolgus macaques by wild-type Puumala hantavirus resulted in typical signs of HFRS including lethargy, anorexia, proteinuria, and/or hematuria, in addition to cytokine (interleukin 6 [IL-6], IL-10, and tumor necrosis factor alpha), C-reactive protein, creatinine, and nitric oxide responses. Viral RNA was detected in plasma from days 3 to 7 postinoculation until days 24 to 28 postinoculation, infectious virus was recovered, and the virus-specific immune responses (immunoglobulin M [IgM], IgG, and neutralizing antibodies) mimicked those seen in humans. The results indicated that the monkey model will provide a valuable tool for studies of pathogenesis, candidate vaccines, and antivirals for hantavirus disease.
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- art (ämneskategori)
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