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DCEO Biotechnology:...
DCEO Biotechnology: Tools to Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals
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- Chen, Xiulai (author)
- Jiangnan University
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- Gao, Cong (author)
- Jiangnan University
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- Guo, Liang (author)
- Jiangnan University
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- Hu, Guipeng (author)
- Jiangnan University
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- Luo, Qiuling (author)
- Jiangnan University
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- Liu, Jia (author)
- Jiangnan University
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- Nielsen, Jens B, 1962 (author)
- Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology
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- Chen, Jian (author)
- Jiangnan University
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- Liu, Liming, 1976 (author)
- Jiangnan University,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2017-04-26
- 2018
- English.
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In: Chemical Reviews. - : American Chemical Society (ACS). - 0009-2665 .- 1520-6890. ; 118:1, s. 4-72
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Abstract
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- Chemical synthesis is a well established route for producing many chemicals on a large scale, but some drawbacks still exist in this process, such as unstable intermediates, multistep reactions, complex process control, etc. Biobased production provides an attractive alternative to these challenges, but how to make cells into efficient factories is challenging. As a key enabling technology to develop efficient cell factories, design-construction-evaluation-optimization (DCEO) biotechnology, which incorporates the concepts and techniques of pathway design, pathway construction, pathway evaluation, and pathway optimization at the systems level, offers a conceptual and technological framework to exploit potential pathways, modify existing pathways and create new pathways for the optimal production of desired chemicals. Here, we summarize recent progress of DCEO biotechnology and examples of its application, and provide insights as to when, what and how different strategies should be taken. In addition, we highlight future perspectives of DCEO biotechnology for the successful establishment of biorefineries.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Produktionsteknik, arbetsvetenskap och ergonomi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Production Engineering, Human Work Science and Ergonomics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Annan maskinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Other Mechanical Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioprocessteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioprocess Technology (hsv//eng)
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- By the author/editor
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Chen, Xiulai
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Gao, Cong
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Guo, Liang
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Hu, Guipeng
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Luo, Qiuling
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Liu, Jia
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show more...
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Nielsen, Jens B, ...
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Chen, Jian
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Liu, Liming, 197 ...
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Mechanical Engin ...
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and Production Engin ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Mechanical Engin ...
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and Other Mechanical ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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and Bioprocess Techn ...
- Articles in the publication
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Chemical Reviews
- By the university
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Chalmers University of Technology