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Recognition and cha...
Recognition and characterization of binding modes of Δ- and Λ-[Ru(phen)3]2+ and Δ- and Λ-[Ru(phen)2DPPZ]2+ by the 23Na NMR Relaxation and Binding Free Energy Parameters
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Marincola, F.C. (author)
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Casu, M. (author)
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Saba, G. (author)
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Lai, A. (author)
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- Lincoln, Per, 1958 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nordén, Bengt, 1945 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: Chemical Physics. - 0301-0104. ; 236:1-3, s. 301-308
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Abstract
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- Na-23 NMR relaxation rates were measured in Na-DNA aqueous solutions in the presence of Delta- or Lambda-enantiomer of [Ru(phen)(3)](2+) and [Ru(phen)(2)DPPZ](2+). From the analysis of the spin-lattice and spin-spin relaxation rates evidence is given that a decrease of the quadrupolar coupling constant for the slow motions occurs, due to the structural and dynamical modifications of DNA induced by the binding of the ruthenium complexes. Furthermore a linear dependence between the changes of the broad component, R-2bB, and the relative polyelectrolyte contributions to the binding free energy, Delta G(pe)/Delta G, was found. In particular for the intercalators Delta- and Lambda-[Ru(phen)(2)DPPZ](2+), a direct dependence on Delta G(pe)/Delta G was observed, as already found for ethidium, propidium and dq2pyp; while [Ru(phen)(3)](2+) complexes and the pure electrostatic Mg2+ showed an inverse dependence. These results have been discussed in terms of the polyelectrolyte interactions responsible for the R-2bB changes.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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