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A Molybdenum Disulf...
A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis
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- Wang, Longwei (author)
- Chinese Academy of Sciences
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- Zhang, Xiaodi (author)
- Jinan University
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- You, Zhen (author)
- Chinese Academy of Sciences
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- Yang, Zhongwei (author)
- Jinan University
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- Guo, Mengyu (author)
- Chinese Academy of Sciences
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- Guo, Jia Wei (author)
- Jinan University
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- Liu, He (author)
- Chinese Academy of Sciences
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- Zhang, Xiaoyu (author)
- Chinese Academy of Sciences
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- Wang, Zhuo (author)
- Chinese Academy of Sciences
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- Wang, Aizhu (author)
- Jinan University
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- Lv, Yawei (author)
- Hunan University
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- Zhang, Jian, 1989 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Yu, Xin (author)
- Jinan University
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- Liu, Jing (author)
- Chinese Academy of Sciences
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- Chen, Chunying (author)
- Chinese Academy of Sciences
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(creator_code:org_t)
- 2023-02
- 2023
- English.
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In: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 62:11
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Abstract
Subject headings
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- The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Tumor Therapy
- Nanozymes
- Ferroptosis
- Reactive Oxygen Species
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wang, Longwei
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Zhang, Xiaodi
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You, Zhen
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Yang, Zhongwei
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Guo, Mengyu
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Guo, Jia Wei
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show more...
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Liu, He
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Zhang, Xiaoyu
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Wang, Zhuo
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Wang, Aizhu
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Lv, Yawei
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Zhang, Jian, 198 ...
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Yu, Xin
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Liu, Jing
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Chen, Chunying
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
- Articles in the publication
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Angewandte Chemi ...
- By the university
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Chalmers University of Technology