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STRUCTURE OF UVRABC EXCINUCLEASE UV-DAMAGED DNA COMPLEXES STUDIED BY FLOW LINEAR DICHROISM - DNA CURVED BY UVRB AND UVRC
- Takahashi, Masayuki, 1949 (author)
- Bertrandburggraf, E. (author)
- Fuchs, R. P. P. (author)
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- (creator_code:org_t)
- 2001-12-17
- 1992
- English.
- In: FEBS Letters. - : Wiley. - 1873-3468 .- 0014-5793. ; 314:1, s. 10-12
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The interaction between UvrABC excinuclease from Escherichia coli and ultraviolet light- (UV) damaged DNA was studied by flow linear dichroism. The dichroism signal from DNA was drastically decreased in intensity upon incubation with UvrA and UvrB or whole enzyme in the presence of effector ATP. The change was specific for UV-damaged DNA, and a concluded suppressed DNA orientation suggests the wrapping of DNA around the protein. The incubation with the UvrC subunit alone also somewhat reduces the signal, however, in this case the change was smaller and not specific for UV-damaged DNA. The structural modification of DNA, promoted by the (UvrA2-UvrB) complex, probably facilitates or stabilizes the interaction of the UvrC subunit with DNA for the excision.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- dna repair
- uvrabc excinuclease
- protein
- uv damaged
- binding
- escherichia-coli
- protein dna complex
- dna
- linear dichroism
- repair
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- art (subject category)
- ref (subject category)
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- FEBS Letters
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- Chalmers University of Technology
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