Search: id:"swepub:oai:research.chalmers.se:f79baee9-bba0-449e-9ed2-0e7034732211" >
Novel ruthenium-dop...
Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood
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- Duraisamy, Murugesan (author)
- Kaohsiung Medical University,Universiti Sains Malaysia,University of Science, Malaysia,Sri Sivasubramaniya Nadar College of Engineering
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- Elancheziyan, Mari (author)
- Kaohsiung Medical University
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- Eswaran, Muthusankar, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Kaohsiung Medical University
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- Ganesan, Sivarasan (author)
- Kaohsiung Medical University
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- Ansari, Anees A. (author)
- King Saud University College of Science
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- Rajamanickam, Govindaraj (author)
- Sri Sivasubramaniya Nadar College of Engineering
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- Lee, Siew Ling (author)
- Universiti Teknologi Malaysia
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- Tsai, Pei Chien (author)
- Kaohsiung Medical University,Saveetha School of Engineering
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- Chen, Yi Hsun (author)
- Kaohsiung Medical University
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- Ponnusamy, Vinoth Kumar (author)
- Kaohsiung Medical University,National Sun Yat-Sen University
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: International Journal of Biological Macromolecules. - 0141-8130 .- 1879-0003. ; 244
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https://doi.org/10.1...
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Abstract
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- The use of advanced electroactive catalysts enhances the performance of electrochemical biosensors in real-time biomonitoring and has received much attention owing to its excellent physicochemical and electrochemical possessions. In this work, a novel biosensor was developed based on the electrocatalytic activity of functionalized vanadium carbide (VC) material, including VC@ruthenium (Ru), VC@Ru-polyaniline nanoparticles (VC@Ru-PANI-NPs) as non-enzymatic nanocarriers for the fabrication of modified screen-printed electrode (SPE) to detect acetaminophen in human blood. As-prepared materials were characterized using SEM, TEM, XRD, and XPS techniques. Biosensing was carried out using cyclic voltammetry and differential pulse voltammetry techniques and has revealed imperative electrocatalytic activity. A quasi-reversible redox method of the over-potential of acetaminophen increased considerably compared with that at the modified electrode and the bare SPE. The excellent electrocatalytic behaviour of VC@Ru-PANI-NPs/SPE is attributed to its distinctive chemical and physical properties, including rapid electron transfer, striking ᴫ-ᴫ interface, and strong adsorptive capability. This electrochemical biosensor exhibits a detection limit of 0.024 μM, in a linear range of 0.1–382.72 μM with a reproducibility of 2.45 % relative standard deviation, and a good recovery from 96.69 % to 105.59 %, the acquired results ensure a better performance compared with previous reports. The enriched electrocatalytic activity of this developed biosensor is mainly credited to its high surface area, better electrical conductivity, synergistic effect, and abundant electroactive sites. The real-world utility of the VC@Ru-PANI-NPs/SPE-based sensor was ensured via the investigation of biomonitoring of acetaminophen in human blood samples with satisfactory recoveries.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Electrochemical sensor
- Conductive polymer
- Two-dimensional metal carbide
- Human plasma
- Acetaminophen
Publication and Content Type
- art (subject category)
- ref (subject category)
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Duraisamy, Murug ...
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Elancheziyan, Ma ...
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Eswaran, Muthusa ...
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Ganesan, Sivaras ...
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Ansari, Anees A.
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Rajamanickam, Go ...
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Lee, Siew Ling
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Tsai, Pei Chien
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Chen, Yi Hsun
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Ponnusamy, Vinot ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Analytical Chemi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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Chalmers University of Technology