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Population pharmaco...
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Tchaparian, E.
(författare)
Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-07-28
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Oxford University Press (OUP),2016
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:du-23296
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-23296URI
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https://doi.org/10.1093/infdis/jiw338DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background. The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children. Methods. Capillary whole-blood lumefantrine concentration and treatment outcomes were determined in 105 Ugandan children, ages 6 months to 2 years, who were treated for 249 episodes of Plasmodium falciparum malaria with artemether-lumefantrine. Results. Population pharmacokinetics for lumefantrine used a 2-compartment open model with first-order absorption. Age had a significant positive correlation with bioavailability in a model that included allometric scaling. Children not receiving trimethoprim-sulfamethoxazole with capillary whole blood concentrations <200 ng/mL had a 3-fold higher hazard of 28-day recurrent parasitemia, compared with those with concentrations >200 ng/mL (P =. 0007). However, for children receiving trimethoprim-sulfamethoxazole, the risk of recurrent parasitemia did not differ significantly on the basis of this threshold. Day 3 concentrations were a stronger predictor of 28-day recurrence than day 7 concentrations. Conclusions. We demonstrate that age, in addition to weight, is a determinant of lumefantrine exposure, and in the absence of trimethoprim-sulfamethoxazole, lumefantrine exposure is a determinant of recurrent parasitemia. Exposure levels in children aged 6 months to 2 years was generally lower than levels published for older children and adults. Further refinement of artemether-lumefantrine dosing to improve exposure in infants and very young children may be warranted. © 2016 The Author.
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Sambol, N.C.
(författare)
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Arinaitwe, E.
(författare)
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McCormack, S.A.
(författare)
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Bigira, V.
(författare)
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Wanzira, H.
(författare)
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Blessborn, Daniel
(författare)
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Bergqvist, YngveHögskolan Dalarna,Medicinsk vetenskap(Swepub:du)ybq
(författare)
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Aweeka, F.T.
(författare)
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Parikh, S.
(författare)
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Högskolan DalarnaMedicinsk vetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Infectious Diseases: Oxford University Press (OUP)214:8, s. 1243-12510022-18991537-6613
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Tchaparian, E.
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Sambol, N.C.
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Arinaitwe, E.
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McCormack, S.A.
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Bigira, V.
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Wanzira, H.
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visa fler...
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Blessborn, Danie ...
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Bergqvist, Yngve
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Aweeka, F.T.
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Parikh, S.
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Högskolan Dalarna