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Sökning: onr:"swepub:oai:DiVA.org:du-29863" > Albuminuria as a pr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003925naa a2200517 4500
001oai:DiVA.org:du-29863
003SwePub
008190408s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:141771874
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-298632 URI
0247 a https://doi.org/10.1161/JAHA.118.0105462 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1417718742 URI
040 a (SwePub)dud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mok, Yejin4 aut
2451 0a Albuminuria as a predictor of cardiovascular outcomes in patients with acute myocardial infarction
264 1c 2019
338 a electronic2 rdacarrier
520 a Background. In patients with myocardial infarction ( MI ), reduced kidney function is recognized as an important predictor of poor prognosis, but the impact of albuminuria, a representative measure of kidney damage, has not been extensively evaluated.Methods and Results. In the SCREAM (Stockholm Creatinine Measurements) project (2006-2012), we identified 2469 patients with incident MI with dipstick proteinuria measured within a year before MI (427 patients also had urine albumin to creatinine ratio [ ACR ] measured concurrently) and obtained estimates for ACR with multiple imputation in participants with data solely on dipstick proteinuria. We quantified the association of ACR with the post- MI composite and individual outcomes of all-cause mortality, cardiovascular mortality, recurrent MI , ischemic stroke, or heart failure using Cox models and then evaluated the improvement in C statistic. During a median follow-up of 1.0 year after MI , 1607 participants (65.1%) developed the post- MI composite outcome. Higher ACR levels were independently associated with all outcomes except for ischemic stroke. Per 8-fold higher ACR (eg, 40 versus 5 mg/g), the hazard ratio of composite outcome was 1.21 (95% CI , 1.08-1.35). The addition of the ACR improved the C statistic of the post- MI composite by 0.040 (95% CI, 0.030-0.051). Largely similar results were obtained regardless of diabetic status and when ACR or dipstick was separately analyzed without imputation.Conclusions. In patients with MI , albuminuria was a potent predictor of subsequent outcomes, suggesting the importance of paying attention to the information on albuminuria, in addition to kidney function, in this high-risk population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a albuminuria
653 a chronic kidney disease
653 a myocardial infarction
653 a prognosis
653 a Hälsa och välfärd
653 a Health and Welfare
7001 a Ballew, Shoshana H4 aut
7001 a Sang, Yingying4 aut
7001 a Grams, Morgan Eu Karolinska Institutet4 aut
7001 a Coresh, Josef4 aut
7001 a Evans, Marie4 aut
7001 a Barany, Peteru Karolinska Institutet4 aut
7001 a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet4 aut0 (Swepub:du)jan
7001 a Carrero, Juan-Jesusu Karolinska Institutet4 aut
7001 a Matsushita, Kunihiro4 aut
7102 a Karolinska Institutetb Medicinsk vetenskap4 org
7730 t Journal of the American Heart Associationg 8:8q 8:8x 2047-9980
8564 u https://doi.org/10.1161/JAHA.118.010546y Fulltext
8564 u https://du.diva-portal.org/smash/get/diva2:1302930/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-29863
8564 8u https://doi.org/10.1161/JAHA.118.010546
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141771874

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