Sökning: onr:"swepub:oai:DiVA.org:kth-134721" >
A comparative study...
A comparative study of dissociation of thymidine molecules following valence or core photoionization
-
Itala, E. (författare)
-
Huels, M. A. (författare)
-
- Rachlew, Elisabeth (författare)
- KTH,Atom- och molekylfysik
-
visa fler...
-
Kooser, K. (författare)
-
Hagerth, T. (författare)
-
Kukk, E. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2013-10-28
- 2013
- Engelska.
-
Ingår i: Journal of Physics B. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 46:21, s. 215102-
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We have studied the fragmentation of gas phase thymidine following valence and core ionization using synchrotron radiation, combined with electron energy and ion mass resolved detection in coincidence. To identify certain fragment masses C-13 labelled thymidine was also used. We find that in large part, the photofragmentation of thymidine can be described as separated thymine and 2-deoxy-D-ribose cations. However, also the intact thymidine radical cation, formation of intact base and sugar cations from glycosidic bond cleavage and several new thymidine-specific fragments are observed after valence ionization. Conversely, at the photoionization of C 1s electrons neither parent thymidine cations nor any fragments above 55 amu were detected, and only ion pairs with small masses survive core ionization, Auger decay and the subsequent Coulomb separation of the DNA sub-unit. This demonstrates the genotoxic nature of soft x-rays which in cells induce complex clustered damage similar to those yielded by heavy particles.
Ämnesord
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- Electron-Impact
- Gas-Phase
- 2-Deoxy-D-Ribose Molecules
- Coincidence Technique
- Triple Coincidence
- Condensed-Phase
- Fragmentation
- Ionization
- Uracil
- Photofragmentation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas