Sökning: onr:"swepub:oai:DiVA.org:kth-149211" > Affinity proteomics...
Fältnamn | Indikatorer | Metadata |
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000 | 04772naa a2200721 4500 | |
001 | oai:DiVA.org:kth-149211 | |
003 | SwePub | |
008 | 140818s2014 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-230504 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1492112 URI |
024 | 7 | a https://doi.org/10.15252/emmm.2013037242 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2305042 URI |
040 | a (SwePub)kthd (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ayoglu, Burcuu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1kfjubd |
245 | 1 0 | a Affinity proteomics within rare diseases :b a BIO-NMD study for blood biomarkers of muscular dystrophies |
264 | c 2014-06-11 | |
264 | 1 | b EMBO,c 2014 |
338 | a print2 rdacarrier | |
500 | a QC 20140819 | |
520 | a Despite the recent progress in the broad-scaled analysis of proteins in body fluids, there is still a lack in protein profiling approaches for biomarkers of rare diseases. Scarcity of samples is the main obstacle hindering attempts to apply discovery driven protein profiling in rare diseases. We addressed this challenge by combining samples collected within the BIO-NMD consortium from four geographically dispersed clinical sites to identify protein markers associated with muscular dystrophy using an antibody bead array platform with 384 antibodies. Based on concordance in statistical significance and confirmatory results obtained from analysis of both serum and plasma, we identified eleven proteins associated with muscular dystrophy, among which four proteins were elevated in blood from muscular dystrophy patients: carbonic anhydrase III (CA3) and myosin light chain 3 (MYL3), both specifically expressed in slow-twitch muscle fibers and mitochondrial malate dehydrogenase 2 (MDH2) and electron transfer flavo-protein A (ETFA). Using age-matched sub-cohorts, 9 protein profiles correlating with disease progression and severity were identified, which hold promise for the development of new clinical tools for management of dystrophinopathies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a antibody-based proteomics | |
653 | a disease severity biomarkers | |
653 | a Duchenne muscular dystrophy | |
653 | a plasma profilling | |
653 | a protein profiling | |
700 | 1 | a Chaouch, Amina4 aut |
700 | 1 | a Lochmüller, Hanns4 aut |
700 | 1 | a Politano, Luisa4 aut |
700 | 1 | a Bertini, Enrico4 aut |
700 | 1 | a Spitali, Pietro4 aut |
700 | 1 | a Hiller, Monika4 aut |
700 | 1 | a Niks, Eric H.4 aut |
700 | 1 | a Gualandi, Francesca4 aut |
700 | 1 | a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fredpont |
700 | 1 | a Bushby, Kate4 aut |
700 | 1 | a Aartsma-Rus, Annemieke4 aut |
700 | 1 | a Schwartz, Elena4 aut |
700 | 1 | a Le Priol, Yannick4 aut |
700 | 1 | a Straub, Volker4 aut |
700 | 1 | a Uhlén, Mathiasu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw |
700 | 1 | a Cirak, Sebahattin4 aut |
700 | 1 | a 't Hoen, Peter A. C.4 aut |
700 | 1 | a Muntoni, Francesco4 aut |
700 | 1 | a Ferlini, Alessandra4 aut |
700 | 1 | a Schwenk, Jochen M.u KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1h7wtme |
700 | 1 | a Nilsson, Peteru KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ws88sk |
700 | 1 | a Szigyarto, Cristina Al-Khalili4 aut |
710 | 2 | a KTHb Proteomik och nanobioteknologi4 org |
773 | 0 | t EMBO Molecular Medicined : EMBOg 6:7, s. 918-936q 6:7<918-936x 1757-4676x 1757-4684 |
856 | 4 | u https://doi.org/10.15252/emmm.201303724 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-149211 |
856 | 4 8 | u https://doi.org/10.15252/emmm.201303724 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230504 |
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