onr:"swepub:oai:DiVA.org:kth-178197"
Sökning: onr:"swepub:oai:DiVA.org:kth-178197" > The SNF2-like helic...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02892naa a2200493 4500 | |
| 001 | oai:DiVA.org:kth-178197 | |
| 003 | SwePub | |
| 008 | 151207s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1781972 URI |
| 024 | 7 | a https://doi.org/10.1038/emboj.2011.4512 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a von Eyss, Björn4 aut |
| 245 | 1 0 | a The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. |
| 264 | c 2011-12-13 | |
| 264 | 1 | b Nature Publishing Group,c 2012 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 2016-02-05 | |
| 520 | a The activating E2F-transcription factors are best known for their dependence on the Retinoblastoma protein and their role in cellular proliferation. E2F3 is uniquely amplified in specific human tumours where its expression is inversely correlated with the survival of patients. Here, E2F3B interaction partners were identified by mass spectrometric analysis. We show that the SNF2-like helicase HELLS interacts with E2F3A in vivo and cooperates with its oncogenic functions. Depletion of HELLS severely perturbs the induction of E2F-target genes, hinders cell-cycle re-entry and growth. Using chromatin immmunoprecipitation coupled to sequencing, we identified genome-wide targets of HELLS and E2F3A/B. HELLS binds promoters of active genes, including the trithorax-related MLL1, and co-regulates E2F3-dependent genes. Strikingly, just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours. Our work reveals that HELLS is important for E2F3 in tumour cell proliferation. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
| 653 | a cell-cycle re-entry | |
| 653 | a E2F3 | |
| 653 | a HELLS | |
| 653 | a H3K27me3 | |
| 653 | a prostate tumour | |
| 700 | 1 | a Maaskola, Jonas4 aut |
| 700 | 1 | a Memczak, Sebastian4 aut |
| 700 | 1 | a Möllmann, Katharina4 aut |
| 700 | 1 | a Schuetz, Anja4 aut |
| 700 | 1 | a Loddenkemper, Christoph4 aut |
| 700 | 1 | a Tanh, Mai-Dinh4 aut |
| 700 | 1 | a Otto, Albrecht4 aut |
| 700 | 1 | a Muegge, Kathrin4 aut |
| 700 | 1 | a Heinemann, Udo4 aut |
| 700 | 1 | a Rajewsky, Nikolaus4 aut |
| 700 | 1 | a Ziebold, Ulrike4 aut |
| 773 | 0 | t EMBO Journald : Nature Publishing Groupg 31:4, s. 972-985q 31:4<972-985x 0261-4189x 1460-2075 |
| 856 | 4 | u https://europepmc.org/articles/pmc3280551?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-178197 |
| 856 | 4 8 | u https://doi.org/10.1038/emboj.2011.451 |
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