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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005504naa a2200697 4500
001oai:DiVA.org:kth-198898
003SwePub
008161222s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:134650347
009oai:lup.lub.lu.se:097f71cd-08ca-43cd-8385-7cf8f9a4e08a
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1988982 URI
0247 a https://doi.org/10.1080/08916934.2016.11836552 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1346503472 URI
0247 a https://lup.lub.lu.se/record/097f71cd-08ca-43cd-8385-7cf8f9a4e08a2 URI
040 a (SwePub)kthd (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Häggmark-Månberg, Annau KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1g5roxd
2451 0a Autoantibody targets in vaccine-associated narcolepsy
264 c 2016-05-20
264 1b Taylor & Francis,c 2016
338 a print2 rdacarrier
500 a QC 20170109
520 a Narcolepsy is a chronic sleep disorder with a yet unknown cause, but the specific loss of hypocretin-producing neurons together with a strong human leukocyte antigen (HLA) association has led to the hypothesis that autoimmune mechanisms might be involved. Here, we describe an extensive effort to profile autoimmunity repertoires in serum with the aim to find disease-related autoantigens. Initially, 57 serum samples from vaccine-associated and sporadic narcolepsy patients and controls were screened for IgG reactivity towards 10 846 fragments of human proteins using planar microarrays. The discovered differential reactivities were verified on suspension bead arrays in the same sample collection followed by further investigation of 14 antigens in 176 independent samples, including 57 narcolepsy patients. Among these 14 antigens, methyltransferase-like 22 (METTL22) and 5'-nucleotidase cytosolic IA (NT5C1A) were recognized at a higher frequency in narcolepsy patients of both sample sets. Upon sequence analysis of the 14 proteins, polymerase family, member 3 (PARP3), acyl-CoA-binding domain containing 7 (ARID4B), glutaminase 2 (GLS2) and cyclin-dependent kinase-like 1 (CDKL1) were found to contain amino acid sequences with homology to proteins found in the H1N1 vaccine. These findings could become useful elements of further clinical assays that aim towards a better phenotypic understanding of narcolepsy and its triggers.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Narcolepsy
653 a autoantibody
653 a vaccine-associated
653 a protein microarray
653 a serum
653 a autoantibody
653 a Narcolepsy
653 a protein microarray
653 a serum
653 a vaccine-associated
7001 a Zandian, Arashu KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11qiehv
7001 a Forsström, Björnu KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11i5nju
7001 a Khademi, Mohsenu Karolinska Institutet4 aut
7001 a Bomfim, Izaura Limau Karolinska Institutet4 aut
7001 a Hellström, Ceciliau KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1doy1fn
7001 a Arnheim-Dahlström, Lisenu Karolinska Institutet4 aut
7001 a Hallböök, Toveu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-tha
7001 a Darin, Niklas4 aut
7001 a Lundberg, Ingrid E.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Uhlén, Mathiasu KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1dulvmw
7001 a Partinen, Markkuu University of Helsinki4 aut
7001 a Schwenk, Jochen M.u KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1h7wtme
7001 a Olsson, Tomasu Karolinska Institutet4 aut
7001 a Nilsson, Peteru KTH Royal Institute of Technology,KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ws88sk
7102 a KTHb Science for Life Laboratory, SciLifeLab4 org
7730 t Autoimmunityd : Taylor & Francisg 49:6, s. 421-433q 49:6<421-433x 0891-6934x 1607-842X
8564 u http://dx.doi.org/10.1080/08916934.2016.1183655y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-198898
8564 8u https://doi.org/10.1080/08916934.2016.1183655
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134650347
8564 8u https://lup.lub.lu.se/record/097f71cd-08ca-43cd-8385-7cf8f9a4e08a

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