onr:"swepub:oai:DiVA.org:kth-27978"
Sökning: onr:"swepub:oai:DiVA.org:kth-27978" > A Pyrosequencing St...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04946naa a2200613 4500 | |
| 001 | oai:DiVA.org:kth-27978 | |
| 003 | SwePub | |
| 008 | 110103s2010 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-24208 | |
| 009 | oai:prod.swepub.kib.ki.se:121672394 | |
| 009 | oai:slubar.slu.se:61170 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279782 URI |
| 024 | 7 | a https://doi.org/10.1053/j.gastro.2010.08.0492 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-242082 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1216723942 URI |
| 024 | 7 | a https://res.slu.se/id/publ/611702 URI |
| 040 | a (SwePub)kthd (SwePub)orud (SwePub)kid (SwePub)slu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Willing, Ben P.u Dept Microbiol, Swedish Univ Agr Sci, Uppsala, Sweden4 aut |
| 245 | 1 0 | a A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes |
| 264 | 1 | b Elsevier BV,c 2010 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20110103 | |
| 520 | a BACKGROUND & AIMS: The composition of the gastrointestinal microbiota is thought to have an important role in the etiology of inflammatory bowel diseases (IBDs) such as Crohn's disease (CD) and ulcerative colitis (UC). Interindividual variation and an inability to detect less abundant bacteria have made it difficult to correlate specific bacteria with disease. METHODS: We used 454 pyrotag sequencing to determine the compositions of microbial communities in feces samples collected from a cohort of 40 twin pairs who were concordant or discordant for CD or UC, and in mucosal samples from a subset of the cohort. The cohort primarily comprised patients who were in remission, but also some with active disease. RESULTS: The profiles of the microbial community differed with disease phenotypes; relative amounts of bacterial populations correlated with IBD phenotypes. The microbial compositions of individuals with CD differed from those of healthy individuals, but were similar between healthy individuals and individuals with UC. Profiles from individuals with CD that predominantly involved the ileum differed from those with CD that predominantly involved the colon; several bacterial populations increased or decreased with disease type. Changes specific to patients with ileal CD included the disappearance of core bacteria, such as Faecalibacterium and Roseburia, and increased amounts of Enterobacteriaceae and Ruminococcus gnavus. CONCLUSIONS: Bacterial populations differ in abundance among individuals with different phenotypes of CD. Specific species of bacteria are associated with ileal CD; further studies should investigate their role in pathogenesis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 653 | a Gastrointestinal Microbiome | |
| 653 | a CCD | |
| 653 | a ICD | |
| 653 | a Pyrosequencing | |
| 653 | a Microbial Profiling | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 653 | a Medicine | |
| 700 | 1 | a Dicksved, Johanu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology4 aut0 (Swepub:slu)47518 |
| 700 | 1 | a Halfvarson, Jonasu Dept Med, Div Gastroenterol, Örebro Univ Hosp, Örebro, Sweden4 aut0 (Swepub:oru)jshn |
| 700 | 1 | a Andersson, Anders F.u KTH,Genteknologi,Dept Bacteriol, Swedish Inst Infect Dis Control, Solna, Sweden4 aut0 (Swepub:kth)u1hi776x |
| 700 | 1 | a Lucio, Mariannau Res Ctr Environ, Inst Ecol Chem, Helmholtz Zentrum Muenchen, Neuherberg, Germany4 aut |
| 700 | 1 | a Zheng, Zongliu Karolinska Institutet4 aut |
| 700 | 1 | a Jarnerot, Gunnaru Dept Med, Div Gastroenterol, Örebro Univ Hosp, Örebro, Sweden4 aut |
| 700 | 1 | a Tysk, Curtu Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)ctk |
| 700 | 1 | a Jansson, Janetu Lawrence Berkeley Lab, Div Earth Sci, Univ Calif Berkeley, Berkeley CA, USA,Lawrence Berkeley National Laboratory (Berkeley Lab)4 aut0 (Swepub:slu)51483 |
| 700 | 1 | a Engstrand, Larsu Karolinska Institutet4 aut |
| 710 | 2 | a Dept Microbiol, Swedish Univ Agr Sci, Uppsala, Swedenb Institutionen för mikrobiologi4 org |
| 710 | 2 | a Sveriges lantbruksuniversitet |
| 773 | 0 | t Gastroenterologyd : Elsevier BVg 139:6, s. 1844-U105q 139:6<1844-U105x 0016-5085x 1528-0012 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-27978 |
| 856 | 4 8 | u https://doi.org/10.1053/j.gastro.2010.08.049 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-24208 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121672394 |
| 856 | 4 8 | u https://res.slu.se/id/publ/61170 |
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