3D Co-cultured Endothelial Cells and Monocytes Promoted Cancer Stem Cells' Stemness and Malignancy

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Fältnamn	Indikatorer	Metadata
000		03909naa a2200649 4500
001		oai:DiVA.org:kth-292825
003		SwePub
008		210415s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:235014295
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2928252 URI
024	7	a https://doi.org/10.1021/acsabm.0c009272 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2350142952 URI
040		a (SwePub)kthd (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Qiao, S.4 aut
245	1 0	a 3D Co-cultured Endothelial Cells and Monocytes Promoted Cancer Stem Cells' Stemness and Malignancy
264		c 2020-12-15
264	1	b American Chemical Society,c 2021
338		a print2 rdacarrier
500		a QC 20210525
520		a Cancer stem cells (CSCs) are self-renewing and constitute the primary cause of cancer relapse post-cancer therapy. The CSC niche is composed of various nonmalignant stromal cells that support CSCs' survival during cancer chemoradiotherapy. Understanding the cross-talk between CSCs and stromal cells could pave the way for developing therapeutic strategies to eradicate CSCs. Traditionally, CSC research has been relying on animal models, which can give rise to complications and poor translation in clinical practice. An efficient model to co-culture CSCs and stromal cells is urgently needed. Hence, we leveraged our expertise in enriching CSCs from in vitro cell lines with a 3D alginate-based platform, as reported previously. We established a 3D co-culture system that allowed us to study the interactions between stromal cells and CSCs over an extended period. We showed that the self-renewal capacity and stemness of CSCs were significantly enhanced when co-cultured with 3D cultured human umbilical vein endothelial cells (HUVECs) or a human monocyte cell line (THP1). Strikingly, the expression of MDR1 in 3D co-cultured CSCs was upregulated, leading to enhanced chemotoxic drug tolerance. We suggest that our in vitro co-culture model can impact CSC research and clinical practice when the goal is to develop therapeutics that target and eradicate CSCs by targeting stromal cells.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
653		a 3D co-culture
653		a cancer stem cell
653		a hydrogel
653		a paracrine
653		a stromal cells
653		a Cell culture
653		a Clinical research
653		a Endothelial cells
653		a Stem cells
653		a Cancer stem cells
653		a Cancer therapy
653		a Clinical practices
653		a Co-culture system
653		a Drug tolerance
653		a Human monocytes
653		a Human umbilical vein endothelial cells
653		a Therapeutic strategy
653		a Diseases
700	1	a Zhao, Y.4 aut
700	1	a Tian, H.4 aut
700	1	a Manike, I.4 aut
700	1	a Ma, L.4 aut
700	1	a Yan, Hongjiu Karolinska Institutet,KTH,Glykovetenskap4 aut0 (Swepub:kth)u1qjm063
700	1	a Tian, W.4 aut
710	2	a KTHb Glykovetenskap4 org
773	0	t ACS Applied Bio Materialsd : American Chemical Societyg 4:1, s. 441-450q 4:1<441-450x 2576-6422
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-292825
856	4 8	u https://doi.org/10.1021/acsabm.0c00927
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:235014295

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Av författaren/redakt...: Qiao, S.; Zhao, Y.; Tian, H.; Manike, I.; Ma, L.; Yan, Hongji; visa fler...; Tian, W.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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