Sökning: onr:"swepub:oai:DiVA.org:kth-331444" > An integrated cell ...
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000 | 22488naa a2201477 4500 | |
001 | oai:DiVA.org:kth-331444 | |
003 | SwePub | |
008 | 230710s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3314442 URI |
024 | 7 | a https://doi.org/10.1038/s41591-023-02327-22 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sikkema, Lisau Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany4 aut |
245 | 1 0 | a An integrated cell atlas of the lung in health and disease |
264 | 1 | b Springer Nature,c 2023 |
338 | a print2 rdacarrier | |
500 | a QC 20230710 | |
520 | a Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of individual studies and capture the variability present in the population. Here we present the integrated Human Lung Cell Atlas (HLCA), combining 49 datasets of the human respiratory system into a single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents a consensus cell type re-annotation with matching marker genes, including annotations of rare and previously undescribed cell types. Leveraging the number and diversity of individuals in the HLCA, we identify gene modules that are associated with demographic covariates such as age, sex and body mass index, as well as gene modules changing expression along the proximal-to-distal axis of the bronchial tree. Mapping new data to the HLCA enables rapid data annotation and interpretation. Using the HLCA as a reference for the study of disease, we identify shared cell states across multiple lung diseases, including SPP1 + profibrotic monocyte-derived macrophages in COVID-19, pulmonary fibrosis and lung carcinoma. Overall, the HLCA serves as an example for the development and use of large-scale, cross-dataset organ atlases within the Human Cell Atlas. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Ramírez-Suástegui, Cirou Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA, La Jolla4 aut |
700 | 1 | a Strobl, Daniel C.u Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Institute of Clinical Chemistry and Pathobiochemistry, TUM School of Medicine, Technical University of Munich, Munich, Germany4 aut |
700 | 1 | a Gillett, Tessa E.u Experimental Pulmonary and Inflammatory Research, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Zappia, Lukeu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Department of Mathematics, Technical University of Munich, Garching, Germany4 aut |
700 | 1 | a Madissoon, Elou Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a Markov, Nikolay S.u Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA4 aut |
700 | 1 | a Zaragosi, Laure Emmanuelleu Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France4 aut |
700 | 1 | a Ji, Yugeu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany4 aut |
700 | 1 | a Ansari, Meshalu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Arguel, Marie Jeanneu Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France4 aut |
700 | 1 | a Apperloo, Leonieu Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Banchero, Martinu Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Bécavin, Christopheu Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France4 aut |
700 | 1 | a Berg, Marijnu Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Chichelnitskiy, Evgenyu Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany4 aut |
700 | 1 | a Chung, Mei i.u Translational Genomics Research Institute, Phoenix, AZ, USA4 aut |
700 | 1 | a Collin, Antoineu Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France; 3IA Côte d’Azur, Nice, France4 aut |
700 | 1 | a Gay, Aurore C.A.u Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Gote-Schniering, Janineu Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Hooshiar Kashani, Baharaku Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Inecik, Kemalu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany4 aut |
700 | 1 | a Jain, Manuu Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA4 aut |
700 | 1 | a Kapellos, Theodore S.u Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany4 aut |
700 | 1 | a Kole, Tessa M.u Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Leroy, Sylvieu Pulmonology Department, Fédération Hospitalo-Universitaire OncoAge, Centre Hospitalier Universitaire de Nice, Université Côte d’Azur, Nice, France4 aut |
700 | 1 | a Mayr, Christoph H.u Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Oliver, Amanda J.u Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a von Papen, Michaelu Research, Development and Innovation, Comma Soft, Bonn, Germany4 aut |
700 | 1 | a Peter, Lanceu Translational Genomics Research Institute, Phoenix, AZ, USA4 aut |
700 | 1 | a Taylor, Chase J.u Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA4 aut |
700 | 1 | a Walzthoeni, Thomasu Core Facility Genomics, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Xu, Chuanu Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a Bui, Linh T.u Translational Genomics Research Institute, Phoenix, AZ, USA4 aut |
700 | 1 | a De Donno, Carlou Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Dony, Leanderu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany; Department of Translational Psychiatry, Max Planck Institute of Psychiatry and International Max Planck Research School for Translational Psychiatry, Munich, Germany4 aut |
700 | 1 | a Faiz, Alenu Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; School of Life Sciences, Respiratory Bioinformatics and Molecular Biology, University of Technology Sydney, Sydney, Australia4 aut |
700 | 1 | a Guo, Minzheu Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, US4 aut |
700 | 1 | a Gutierrez, Austin J.u Translational Genomics Research Institute, Phoenix, AZ, USA4 aut |
700 | 1 | a Heumos, Lukasu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Huang, Niu Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a Ibarra, Ignacio L.u Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Jackson, Nathan D.u Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA4 aut |
700 | 1 | a Kadur Lakshminarasimha Murthy, Preetishu Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA; Department of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL, USA4 aut |
700 | 1 | a Lotfollahi, Mohammadu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a Tabib, Tracyu Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA4 aut |
700 | 1 | a Talavera-López, Carlosu Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Division of Infectious Diseases and Tropical Medicine, Klinikum der Lüdwig-Maximilians-Universität, Munich, Germany4 aut |
700 | 1 | a Travaglini, Kyle J.u Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Allen Institute for Brain Science, Seattle, WA, USA4 aut |
700 | 1 | a Wilbrey-Clark, Annau Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a Worlock, Kaylee B.u Department of Respiratory Medicine, Division of Medicine, University College London, London, UK4 aut |
700 | 1 | a Yoshida, Masahirou Department of Respiratory Medicine, Division of Medicine, University College London, London, UK4 aut |
700 | 1 | a Chen, Yuexinu Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Hagood, James S.u Department of Pediatrics (Pulmonology), University of North Carolina at Chapel Hill, Chapel Hill, NC, USA4 aut |
700 | 1 | a Agami, Ahmedu Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Horvath, Peteru Biological Research Centre, Szeged, Hungary; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Lundeberg, Joakimu KTH,Genteknologi4 aut0 (Swepub:kth)u1qkn9kw |
700 | 1 | a Marquette, Charles Hugou Pulmonology Department, Fédération Hospitalo-Universitaire OncoAge, Centre Hospitalier Universitaire de Nice, Université Côte d’Azur, Nice, France4 aut |
700 | 1 | a Pryhuber, Gloriau Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA4 aut |
700 | 1 | a Samakovlis, Chistosu Lab and Department of Molecular Bioscience, Stockholm University, Stockholm, Sweden4 aut |
700 | 1 | a Sun, Xinu University of California, San Diego, La Jolla, CA, USA, La Jolla4 aut |
700 | 1 | a Ware, Lorraine B.u Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA4 aut |
700 | 1 | a Zhang, Kunu University of California, San Diego, La Jolla, CA, USA, La Jolla4 aut |
700 | 1 | a van den Berge, Maartenu Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Bossé, Yohanu Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada4 aut |
700 | 1 | a Desai, Tushar J.u Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA4 aut |
700 | 1 | a Eickelberg, Oliveru Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA4 aut |
700 | 1 | a Kaminski, Naftaliu Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA4 aut |
700 | 1 | a Krasnow, Mark A.u Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA4 aut |
700 | 1 | a Lafyatis, Robertu Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA4 aut |
700 | 1 | a Nikolic, Marko Z.u Department of Respiratory Medicine, Division of Medicine, University College London, London, UK4 aut |
700 | 1 | a Powell, Joseph E.u Garvan Institute of Medical Research, Sydney, New South Wales, Australia; Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia4 aut |
700 | 1 | a Rajagopal, Jayaraju Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA4 aut |
700 | 1 | a Rojas, Mauriciou Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH, USA4 aut |
700 | 1 | a Rozenblatt-Rosen, Oritu Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cellular and Tissue Genomics, Genentech, South San Francisco, CA, USA4 aut |
700 | 1 | a Seibold, Max A.u Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA; Department of Pediatrics, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA4 aut |
700 | 1 | a Sheppard, Deanu Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA, USA4 aut |
700 | 1 | a Shepherd, Douglas P.u Department of Physics and Center for Biological Physics, Arizona State University, Tempe, AZ, USA4 aut |
700 | 1 | a Sin, Don D.u Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada4 aut |
700 | 1 | a Timens, Wimu Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Tsankov, Alexander M.u Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA4 aut |
700 | 1 | a Whitsett, Jeffreyu Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA4 aut |
700 | 1 | a Xu, Yanu Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA4 aut |
700 | 1 | a Banovich, Nicholas E.u Translational Genomics Research Institute, Phoenix, AZ, USA4 aut |
700 | 1 | a Barbry, Pascalu Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France; 3IA Côte d’Azur, Nice, France4 aut |
700 | 1 | a Duong, Thu Elizabethu Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, La Jolla, CA, USA, La Jolla4 aut |
700 | 1 | a Falk, Christine S.u Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany4 aut |
700 | 1 | a Meyer, Kerstin B.u Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge4 aut |
700 | 1 | a Kropski, Jonathan A.u Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA4 aut |
700 | 1 | a Pe’er, Danau Howard Hughes Medical Institute, Chevy Chase, MD, USA; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA4 aut |
700 | 1 | a Schiller, Herbert B.u Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Tata, Purushothama Raou Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA4 aut |
700 | 1 | a Schultze, Joachim L.u Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen and University of Bonn, Bonn, Germany4 aut |
700 | 1 | a Teichmann, Sara A.u Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge; Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Misharin, Alexander V.u Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA4 aut |
700 | 1 | a Nawijn, Martijn C.u Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Luecken, Malte D.u Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany4 aut |
700 | 1 | a Theis, Fabian J.u Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany; Department of Mathematics, Technical University of Munich, Garching, Germany4 aut |
710 | 2 | a Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germanyb Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA, La Jolla4 org |
773 | 0 | t Nature Medicined : Springer Natureg 29:6, s. 1563-1577q 29:6<1563-1577x 1078-8956x 1546-170X |
856 | 4 | u https://doi.org/10.1038/s41591-023-02327-2y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-331444 |
856 | 4 8 | u https://doi.org/10.1038/s41591-023-02327-2 |
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