onr:"swepub:oai:DiVA.org:kth-8159"
Sökning: onr:"swepub:oai:DiVA.org:kth-8159" > Detection of gyrA m...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03659naa a2200433 4500 | |
| 001 | oai:DiVA.org:kth-8159 | |
| 003 | SwePub | |
| 008 | 080403s2005 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:115987776 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-81592 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ijantimicag.2005.08.0172 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1159877762 URI |
| 040 | a (SwePub)kthd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gharizadeh, Babacku Stanford Univ, Stanford Genome Technol Ctr4 aut |
| 245 | 1 0 | a Detection of gyrA mutations associated with ciprofloxacin resistance in Neisseria gonorrhoeae by rapid and reliable pre-programmed short DNA sequencing |
| 264 | 1 | b Elsevier BV,c 2005 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20100624 | |
| 520 | a Quinolone resistance is rapidly increasing in Neisseria gonorrhoeae and is posing a significant public health threat that requires constant surveillance. A rapid and reliable mutation detection assay has been developed. The assay is based on pre-programmed short DNA sequencing and is designed to detect point mutations in the gyrA gene that are highly related to ciprofloxacin resistance, i.e. in codons 91 and 95. By developing an assay based on pyrosequencing and exploiting the pre-programmed nucleotide dispensation capability of this technology, the sequence comprising the mutations will be analysed and promptly reveal whether the N. gonorrhoeae pathogen carries resistance to ciprofloxacin. A panel of 40 N. gonorrhoeae clinical isolates, of which 27 phenotypically displayed decreased susceptibility or resistance to ciprofloxacin, was used in the present study. All point mutations in the short stretch of the N. gonorrhoeae gyrA gene were easily discriminated, and the genotypic results obtained by pre-programmed sequencing were mainly in agreement with the phenotypically identified decreased susceptibility or resistance to ciprofloxacin. The new method used in the present study has the potential for rapid and reliable identification of known as well as previously unknown drug resistance mutations. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a DNA sequencing; ciprofloxacin resistance; Neisseria gonorrhoeae; pre-programmed DNA sequencing; pyrosequencing technology; ANTIMICROBIAL RESISTANCE; MECHANISMS; FAILURE; ISOLATE; PARC | |
| 653 | a Biochemistry | |
| 653 | a Biokemi | |
| 700 | 1 | a Akhras, Michaelu KTH,Skolan för bioteknologi (BIO)4 aut0 (Swepub:kth)u1oz2y6y |
| 700 | 1 | a Unemo, Magnusu Örebro Univ Hosp, Dept Clin Microbiol4 aut |
| 700 | 1 | a Wretlind, Bengtu Karolinska Inst, Dept Lab Med4 aut |
| 700 | 1 | a Nyrén, Pålu KTH,Skolan för bioteknologi (BIO)4 aut0 (Swepub:kth)u134qr82 |
| 700 | 1 | a Pourmand, Naderu Stanford Univ, Stanford Genome Technol Ctr4 aut |
| 710 | 2 | a Stanford Univ, Stanford Genome Technol Ctrb Skolan för bioteknologi (BIO)4 org |
| 773 | 0 | t International Journal of Antimicrobial Agentsd : Elsevier BVg 26:6, s. 486-490q 26:6<486-490x 0924-8579x 1872-7913 |
| 856 | 4 | u https://europepmc.org/articles/pmc2768773?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-8159 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ijantimicag.2005.08.017 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115987776 |
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