Sökning: onr:"swepub:oai:DiVA.org:liu-121813" > An imidazole functi...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04045naa a2200505 4500 | |
001 | oai:DiVA.org:liu-121813 | |
003 | SwePub | |
008 | 151007s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1218132 URI |
024 | 7 | a https://doi.org/10.3389/fchem.2015.000582 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Magnusson, Karinu Linköpings universitet,Kemi,Tekniska högskolan4 aut0 (Swepub:liu)karma59 |
245 | 1 0 | a An imidazole functionalized pentameric thiophene displays different staining patterns in normal and malignant cells |
264 | c 2015-10-07 | |
264 | 1 | b Frontiers Media S.A.c 2015 |
338 | a print2 rdacarrier | |
500 | a Vid tiden för disputation förelåg publikationen som manuskriptFunding agencies: Swedish Foundation for Strategic Research; GeCONil [POIG.02.03.01-24-099/13]; ERC from the European Research Council | |
520 | a Molecular tools for fluorescent imaging of cells and their components are vital for understanding the function and activity of cells. Here, we report an imidazole functionalized pentameric oligothiophene, p-HTIm, that can be utilized for fluorescent imaging of cells. p-HTIm fluorescence in normal cells appeared in a peripheral punctate pattern partially co-localized with lysosomes, whereas a one-sided perinuclear Golgi associated localization of the dye was observed in malignant cells. The uptake of p-HTIm was temperature dependent and the intracellular target was reached within 1 h after staining. The ability of p-HTIm to stain cells was reduced when the imidazole side chain was chemically altered, verifying that specific imidazole side-chain functionalities are necessary for achieving the observed cellular staining. Our findings confirm that properly functionalized oligothiophenes can be utilized as fluorescent tools for vital staining of cells and that the selectivity towards distinct intracellular targets are highly dependent on the side-chain functionalities along the conjugated thiophene backbone. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng |
653 | a Oligothiophenes | |
653 | a fluorescence | |
653 | a cells | |
653 | a imaging | |
653 | a imidazole | |
700 | 1 | a Appelqvist, Hannau Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)hanmi48 |
700 | 1 | a Cieślar-Pobuda, Arturu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)artci82 |
700 | 1 | a Bäck, Marcusu Linköpings universitet,Kemi,Tekniska högskolan4 aut0 (Swepub:liu)marba90 |
700 | 1 | a Kågedal, Bertilu Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten4 aut0 (Swepub:liu)berka70 |
700 | 1 | a Jonasson, Jonu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi och klinisk genetik4 aut0 (Swepub:liu)jonjo59 |
700 | 1 | a Los, Marek J.u Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)marlo |
700 | 1 | a Nilsson, Peter R.u Linköpings universitet,Kemi,Tekniska högskolan4 aut0 (Swepub:liu)petni61 |
710 | 2 | a Linköpings universitetb Kemi4 org |
773 | 0 | t Frontiers in Chemistryd : Frontiers Media S.A.g 3q 3x 2296-2646 |
856 | 4 | u https://www.frontiersin.org/articles/10.3389/fchem.2015.00058/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121813 |
856 | 4 8 | u https://doi.org/10.3389/fchem.2015.00058 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy