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Sökning: onr:"swepub:oai:DiVA.org:liu-122203" > The structural and ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03982naa a2200445 4500 | |
| 001 | oai:DiVA.org:liu-122203 | |
| 003 | SwePub | |
| 008 | 151023s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:132077995 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1222032 URI |
| 024 | 7 | a https://doi.org/10.1016/j.actbio.2015.07.0092 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1320779952 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hayes, Sallyu Cardiff University, Wales; Cardiff University, Wales4 aut |
| 245 | 1 0 | a The structural and optical properties of type III human collagen biosynthetic corneal substitutes |
| 264 | 1 | b ELSEVIER SCI LTD,c 2015 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|MRC [503626]; Swedish Research Council [521-2012-5706] | |
| 520 | a The structural and optical properties of clinically biocompatible, cell-free hydrogels comprised of synthetically cross-linked and moulded recombinant human collagen type III (RHCIII) with and without the incorporation of 2-methacryloyloxyethyl phosphorylcholine (MPC) were assessed using transmission electron microscopy (TEM), X-ray scattering, spectroscopy and refractometry. These findings were examined alongside similarly obtained data from 21 human donor corneas. TEM demonstrated the presence of loosely bundled aggregates of fine collagen filaments within both RHCIII and RHCIII-MPC implants, which X-ray scattering showed to lack D-banding and be preferentially aligned in a uniaxial orientation throughout. This arrangement differs from the predominantly biaxial alignment of collagen fibrils that exists in the human cornea. By virtue of their high water content (90%), very fine collagen filaments (2-9 nm) and lack of cells, the collagen hydrogels were found to transmit almost all incident light in the visible spectrum. They also transmitted a large proportion of UV light compared to the cornea which acts as an effective UV filter. Patients implanted with these hydrogels should be cautious about UV exposure prior to regrowth of the epithelium and in-growth of corneal cells into the implants. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng |
| 653 | a Cornea; Collagen; Transplantation; Recombinant protein | |
| 700 | 1 | a Lewis, Phillipu Cardiff University, Wales; Cardiff University, Wales4 aut |
| 700 | 1 | a Islam, Mohammad Mirazulu Karolinska Institutet,Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Doutch, Jamesu Diamond Light Source, England4 aut |
| 700 | 1 | a Sorensen, Thomasu Diamond Light Source, England4 aut |
| 700 | 1 | a White, Tomasu Cardiff University, Wales; Cardiff University, Wales4 aut |
| 700 | 1 | a Griffith, Mayu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Institute, Sweden4 aut0 (Swepub:liu)maygr76 |
| 700 | 1 | a Meek, Keith M.u Cardiff University, Wales; Cardiff University, Wales4 aut |
| 710 | 2 | a Cardiff University, Wales; Cardiff University, Walesb Avdelningen för cellbiologi4 org |
| 773 | 0 | t Acta Biomaterialiad : ELSEVIER SCI LTDg 25, s. 121-130q 25<121-130x 1742-7061x 1878-7568 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:864515/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://doi.org/10.1016/j.actbio.2015.07.009 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122203 |
| 856 | 4 8 | u https://doi.org/10.1016/j.actbio.2015.07.009 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132077995 |
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