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Sökning: onr:"swepub:oai:DiVA.org:liu-126791" > Citrate-selective e...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003836naa a2200397 4500
001oai:DiVA.org:liu-126791
003SwePub
008160405s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1267912 URI
0247 a https://doi.org/10.1016/j.snb.2016.01.0562 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Azzouzi, Sawsenu University of Sousse, Tunisia4 aut
2451 0a Citrate-selective electrochemical mu-sensor for early stage detection of prostate cancer
264 1b ELSEVIER SCIENCE SA,c 2016
338 a print2 rdacarrier
500 a Funding Agencies|NATO Science for Peace (SFP) Project [CBP.NUKR.SFP 984173]; FP7-PEOPLE-IRSES [318053]; SEA-on-a-Chip project [614168]
520 a The extremely specialised anatomical function of citrate inside the prostate, make it one of the preferred biomarkers for early stage detection of prostate cancer. However, current detection methods are seriously limited due to the very low citrate concentrations that need to be measured in order to follow disease progression. In the present work, we report a novel citrate-selective-sensor based on iron (III) phthalocyanine chloride-C-monoamido-Poly-n-Butyl Acrylate (Fe(III)MAPcC1 P n BA) modified gold -electrodes for the electrochemical determination and estimation of the pathophysiological range of citrate. The newly synthesised ionophore has been structurally characterised using Fourier transform infrared (FTIR) and UV-vis spectroscopy. Contact angle measurements and atomic force microscopy (AFM) have been used to investigate the adhesion and morphological properties of the membrane. The developed citrate-selective-electrodes had a Nernstian sensitivity of-19.34 +/- 0.83 mV/decade with a detection limit of about 9 x 10-6M and a linear range from 4 x 10(-5)M to 10(-1) M, which covered the pathologically important clinical range. Electrochemical impedance spectroscopy (EIS) showed very high sensitivity with a lower Limit of detection 1.7 x 10(-9) M and linear detection range (10(-8)-10(-1) M), which is very important not only for the early-stage diagnosis and screening procedures, but also in mapping the stage of the cancer too. (C) 2016 Elsevier B.V. All rights reserved.
650 7a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk laboratorie- och mätteknik0 (SwePub)206012 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Laboratory and Measurements Technologies0 (SwePub)206012 hsv//eng
650 7a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng
653 a Citrate selective ionophore; Potentiometry; Impedance spectroscopy; Prostate cancer; Early-stage detection
7001 a Patra, Hirak Kumaru Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)hirpa77
7001 a Ben Ali, Mouniru University of Sousse, Tunisia4 aut
7001 a Nooredeen Abbas, Mohammedu National Research Centre, Egypt4 aut
7001 a Dridi, Cherifu Centre Research Microelect and Nanotechnol CRMN Sousse, Tunisia4 aut
7001 a Errachid, Abdelhamidu University of Lyon 1, France4 aut
7001 a Turner, Anthonyu Linköpings universitet,Biosensorer och bioelektronik,Tekniska fakulteten4 aut0 (Swepub:liu)anttu13
7102 a University of Sousse, Tunisiab Avdelningen för cellbiologi4 org
7730 t Sensors and actuators. B, Chemicald : ELSEVIER SCIENCE SAg 228, s. 335-346q 228<335-346x 0925-4005x 1873-3077
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126791
8564 8u https://doi.org/10.1016/j.snb.2016.01.056

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