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Sökning: onr:"swepub:oai:DiVA.org:liu-129154" > Novel mechanisms in...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004390naa a2200421 4500
001oai:DiVA.org:liu-129154
003SwePub
008160613s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1291542 URI
0247 a https://doi.org/10.1093/eurheartj/ehv3752 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Lau, Dennis H.u University of Adelaide, Australia; Royal Adelaide Hospital, Australia4 aut
2451 0a Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications
264 c 2015-11-17
264 1b OXFORD UNIV PRESS,c 2016
338 a print2 rdacarrier
500 a Funding Agencies|National Health and Medical Research Council of Australia (NHMRC); University of Adelaide; Lions Medical Research Foundation; Australian Postgraduate Award; Fondation Leducq Structural Alterations in the Myocardium and the Substrate for Cardiac Fibrillation; European Union [EUTRAF-261057]; French National Agency [ANR-10-IAHU-05]; Fondation de France; NHMRC; European Union (FP7 large collaborative project EUTRAF) [261057]; Netherlands Heart Foundation (CVON grant) [2014-09]
520 a Intensive research over the last few decades has seen significant advances in our understanding of the complex mechanisms underlying atrial fibrillation (AF). The epidemic of AF and related hospitalizations has been described as a rising tide with estimates of the global AF burden showing no sign of retreat. There is urgency for effective translational programs in this field to facilitate more individualized and targeted therapy to modify the abnormal atrial substrate responsible for the perpetuation of this arrhythmia. In this review, we chose to focus on several novel aspects of AF pathogenesis whereby practical applications in clinical practice are currently available or potentially not too far away. Specifically, we explored the contribution of atrial fibrosis, epicardial adipose tissue, autonomic nervous system, hyper-coagulability, and focal drivers to adverse atrial remodelling and AF persistence. We also highlighted the potential practical means of monitoring and targeting these factors to achieve better outcomes in patients suffering from this debilitating illness. Emerging data also support a new paradigm for targeting AF substrate with aggressive risk factor management. Finally, multi-disciplinary integrated care approach has shown great promise in improving cardiovascular outcomes of patients with AF along with potential cost savings.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Atrial fibrillation; Pathogenesis; Mechanisms; Substrate; Risk factor management; Integrated care
7001 a Schotten, Ulrichu Maastricht University, Netherlands4 aut
7001 a Mahajan, Rajivu University of Adelaide, Australia; Royal Adelaide Hospital, Australia4 aut
7001 a Antic, Nicholas A.u Repatriat Gen Hospital, Australia; Flinders University of S Australia, Australia4 aut
7001 a Hatem, Stephane N.u Hop La Pitie Salpetriere, France; University of Paris 04, France4 aut
7001 a Pathak, Rajeev K.u University of Adelaide, Australia; Royal Adelaide Hospital, Australia4 aut
7001 a Hendriks, Jeroenu Linköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten,University of Adelaide, Australia; Royal Adelaide Hospital, Australia4 aut0 (Swepub:liu)jerhe83
7001 a Kalman, Jonathan M.u Royal Melbourne Hospital, Australia; University of Melbourne, Australia4 aut
7001 a Sanders, Prashanthanu University of Adelaide, Australia; Royal Adelaide Hospital, Australia4 aut
7102 a University of Adelaide, Australia; Royal Adelaide Hospital, Australiab Maastricht University, Netherlands4 org
7730 t European Heart Journald : OXFORD UNIV PRESSg 37:20, s. 1573-+q 37:20<1573-+x 0195-668Xx 1522-9645
8564 u https://academic.oup.com/eurheartj/article-pdf/37/20/1573/7910930/ehv375.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129154
8564 8u https://doi.org/10.1093/eurheartj/ehv375

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