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Sökning: onr:"swepub:oai:DiVA.org:liu-13987" > Antibody levels in ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004572naa a2200505 4500
001oai:DiVA.org:liu-13987
003SwePub
008060915s2004 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-278701
009oai:prod.swepub.kib.ki.se:1954166
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139872 URI
0247 a https://doi.org/10.1111/j.1365-2796.2004.01406.x2 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2787012 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19541662 URI
040 a (SwePub)liud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Midhagen, Gunnaru Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet4 aut0 (Swepub:liu)gunmi07
2451 0a Antibody levels in adult patients with coeliac disease during gluten free diet a rapid initial decrease of clinical importance
264 1b Wiley,c 2004
338 a print2 rdacarrier
520 a Objective. Analysis of antibodies against tissue transglutaminase (tTG) has been shown valuable in the diagnosis of coeliac disease (CD) but how quickly serum titres decrease after introduction of a gluten-free diet (GFD) is not known in adults. CD is a well-recognized disorder amongst the general population and many persons try a GFD for fairly vague symptoms before they seek medical advice. Therefore, it is important to determine the time that the serologic tests remain predictive of the disease after the introduction of a GFD. Methods. Sera were taken from 22 consecutively biopsy-proven adult patients with CD in connection with the diagnostic biopsy. The patients were followed for 1 year and sera were taken after 1, 3, 6 and 12 months after start of a GFD. Sera were stored at −20 °C and analysed for IgA antibodies against gliadin, endomysium and two different commercial tTG assays based on recombinant human tTG (tTGrh) and guinea-pig liver (tTGgp). Results. Twenty patients could be followed during GFD and all antibody titres fell sharply within 1 month after introduction of a GFD and continued to decline during the survey interval. Thirty days after beginning the diet only 58, 84, 74 and 53% of all patients had positive antibody levels of tTGrh, tTGgp, EmA and AGA respectively. Conclusions. As the antibodies used to confirm the diagnosis of CD fall rapidly and continue to decline following the introduction of a GFD, it is important that health care providers carefully inquire about the possibility of self-prescribed diets before patients sought medical attention.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a antibody response
653 a coeliac disease
653 a diet
653 a MEDICINE
653 a MEDICIN
7001 a Åberg, A-Ku Department of Clinical Microbiology and Immunology, Örebro University Hospital, Örebro4 aut
7001 a Olcén, Peru Department of Clinical Microbiology and Immunology, Örebro University Hospital, Örebro4 aut0 (Swepub:liu)perol69
7001 a Järnerot, G.u Department of Medicine, Örebro University Hospital, Örebro4 aut
7001 a Valdimarsson, T.4 aut
7001 a Dahlbom, Iu Pharmacia Diagnostics, Uppsala4 aut0 (Swepub:uu)indah020
7001 a Hansson, Tonyu Pharmacia Diagnostics, Uppsala, and Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden,Department of Rheumatology, Karolinska Institute4 aut0 (Swepub:uu)tohan021
7001 a Ström, Magnusu Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US4 aut0 (Swepub:liu)magst47
7102 a Linköpings universitetb Gastroenterologi och hepatologi4 org
7730 t Journal of Internal Medicined : Wileyg 256:6, s. 519-524q 256:6<519-524x 0954-6820x 1365-2796
8564 u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7373y Link to Ph.D. Thesis
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13987
8564 8u https://doi.org/10.1111/j.1365-2796.2004.01406.x
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-278701
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1954166

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