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Measuring what matt...
Measuring what matters MOST: validation of the Measure of Ovarian Symptoms and Treatment, a patient-reported outcome measure of symptom burden and impact of chemotherapy in recurrent ovarian cancer
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- King, Madeleine T. (author)
- Univ Sydney, Australia; Univ Sydney, Australia
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- Stockler, Martin R. (author)
- ANZGOG, Australia
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- OConnell, Rachel L. (author)
- Univ Sydney, Australia
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- Buizen, Luke (author)
- Univ Sydney, Australia
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- Joly, Florence (author)
- Ctr Francois Baclesse, France
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- Lanceley, Anne (author)
- UCL, England
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- Hilpert, Felix (author)
- Krankenhaus Jerusalem Hamburg, Germany
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- Okamoto, Aikou (author)
- Jikei Univ, Japan
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- Aotani, Eriko (author)
- Kanagawa Acad Sci and Technol, Japan
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- Bryce, Jane (author)
- IRCCS, Italy
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- Donnellan, Paul (author)
- Galway Univ Hosp, Ireland
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- Oza, Amit (author)
- Univ Toronto, Canada
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- Åvall-Lundqvist, Elisabeth, 1957- (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Karolinska Inst, Sweden
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- Berek, Jonathan S. (author)
- Stanford Comprehens Canc Inst, CA USA
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- Sehouli, Jalid (author)
- AGO Study Grp, Germany,Univ Sydney, Australia
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- Feeney, Amanda (author)
- UCL, England
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- Berton-Rigaud, Dominique (author)
- GINECO, France
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- Costa, Daniel S. J. (author)
- Univ Sydney, Australia
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- Friedlander, Michael L. (author)
- ANZGOG, Australia
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(creator_code:org_t)
- 2017-12-16
- 2018
- English.
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In: Quality of Life Research. - : SPRINGER. - 0962-9343 .- 1573-2649. ; 27:1, s. 59-74
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Gynecologic Cancer Intergroup Symptom Benefit Study (GCIG-SBS) Stage 2 aimed to review, revise, and validate a patient-reported outcome measure (PROM), the Measure of Ovarian Symptoms and Treatment concerns (MOST), developed in GCIG-SBS Stage 1 (MOSTv1, 35 items), and document recurrent ovarian cancer (ROC) symptom burden and benefit. GCIG-SBS Stage 2 recruited patients with platinum-resistant/refractory ROC (PRR-ROC) or potentially platinum-sensitive ROC with aeamp;lt;yenamp;gt; 3 lines of prior chemotherapy (PPS-ROC aeamp;lt;yenamp;gt; 3). Patients completed MOSTv1, QLQ-C30, QLQ-OV28, and FACT-O/FOSI at baseline and before cycle 3 of chemotherapy (pre-C3), and global assessments of change (MOST-Change) pre-C3. Clinicians rated patients cancer-related symptoms, performance status, and adverse events. Convergent and divergent validity (Spearmans correlations), discriminative validity (effect sizes between groups classified by clinician-rated characteristics), and responsiveness (paired t tests in patients expected to experience clinically meaningful change) were assessed. Of 948 recruits, 903 completed PROMs at baseline and 685 pre-C3. Baseline symptom burden was substantial for PRR-ROC and PPS-ROC aeamp;lt;yenamp;gt; 3. MOSTv2 has 24 items and five multi-item scales: abdominal symptoms (MOST-Abdo), disease or treatment-related symptoms (MOST-DorT), chemotherapy-related symptoms (MOST-Chemo), psychological symptoms (MOST-Psych), and MOST-Well-being. Correlations confirmed concurrent and divergent validity. Discriminative validity was confirmed by effect sizes that conformed with a priori hypotheses. MOST-Abdo was responsive to improvements in abdominal symptoms and MOST-Chemo detected the adverse effects of chemotherapy. The MOSTv2 validly quantifies patient-reported symptom burden, adverse effects, and symptom benefit in ROC, and as such is fit-for-purpose for clinical trials of palliative chemotherapy in ROC. Further research is required to assess test-retest reliability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Ovarian cancer; Recurrent ovarian cancer; Platinum sensitive; Platinum resistant; Platinum refractory; Symptom burden; Symptom benefit; Magnitude of clinical benefit; Net health benefit; Patient-reported outcome; PRO; Patient-reported outcome measure; PROM; Quality of life; QOL; Health-related quality of life; HRQOL; HRQL
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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King, Madeleine ...
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Stockler, Martin ...
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OConnell, Rachel ...
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Buizen, Luke
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Joly, Florence
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Lanceley, Anne
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show more...
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Hilpert, Felix
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Okamoto, Aikou
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Aotani, Eriko
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Bryce, Jane
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Donnellan, Paul
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Oza, Amit
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Åvall-Lundqvist, ...
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Berek, Jonathan ...
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Sehouli, Jalid
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Feeney, Amanda
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Berton-Rigaud, D ...
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Costa, Daniel S. ...
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Friedlander, Mic ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Quality of Life ...
- By the university
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Linköping University
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Karolinska Institutet