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Sökning: onr:"swepub:oai:DiVA.org:liu-15136" > Intrinsic differenc...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03819naa a2200457 4500 | |
| 001 | oai:DiVA.org:liu-15136 | |
| 003 | SwePub | |
| 008 | 081017s2010 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:121244547 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151362 URI |
| 024 | 7 | a https://doi.org/10.1002/hed.213172 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1212445472 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nilsson, Cathrine,d 1978-u Linköpings universitet,Experimentell patologi,Hälsouniversitetet4 aut0 (Swepub:liu)catni27 |
| 245 | 1 0 | a Intrinsic differences in cisplatin sensitivity of head and neck cancer celllines correlates to lysosomal pH |
| 264 | c 2009-12-22 | |
| 264 | 1 | b John Wiley & Sons,c 2010 |
| 338 | a print2 rdacarrier | |
| 500 | a The previous status of this article was Manuscript and the working title was Radiation and cisplatin sensitivity in head and neck cancer cells with stem cell properties. | |
| 520 | a Cisplatin is part of the treatment regime of head and neck squamous cell carcinomas (HNSCC). In order to predict the clinical outcome of the treatment, markers for evaluation of the intrinsic cisplatin sensitivity are inquired. In this study we characterize the lysosomal compartment and compare cisplatin sensitivity in five HNSCC lines and normal oral keratinocytes (NOKs). Cisplatin sensitivity differed 3-fold between the least and most sensitive cell lines, and the cisplatin LD50 correlated significantly to lysosomal pH, which varied from 4.3 in NOKs to 4.9 in the most resistant HNSCC line. Lysosomes are acidified by the V0V1-ATPase complex located in the lysosomal membrane. Interestingly, in cell lines exhibiting high lysosomal pH, we found decreased expression of the V0V1-ATPase B2 subunit, possibly explaining the defective acidification. In all cell lines, exposure to cisplatin caused activation of caspase-3. Cisplatin exposure was accompanied by lysosomal membrane permeabilization and inhibition of the llysosomal cathepsins B, D and L partly prevented cell death. No correlation between cisplatin sensitivity and expression of cathepsins B, D and L or secretion of their respective proforms into the culture medium was found in the cell lines studied. We conclude that lysosomal pH and expression of V0V1-ATPase subunits are possible future markers of intrinsic cisplatin sensitivity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a apoptosis | |
| 653 | a cathepsin | |
| 653 | a chemotherapy resistance | |
| 653 | a lysosome | |
| 653 | a V0V1-ATPase | |
| 653 | a Cell biology | |
| 653 | a Cellbiologi | |
| 700 | 1 | a Roberg, Karinu Östergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US4 aut0 (Swepub:liu)karro26 |
| 700 | 1 | a Grafström, Roland C.u Karolinska Institutet4 aut |
| 700 | 1 | a Öllinger, Karinu Östergötlands Läns Landsting,Linköpings universitet,Experimentell patologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik4 aut0 (Swepub:liu)karol56 |
| 710 | 2 | a Linköpings universitetb Experimentell patologi4 org |
| 773 | 0 | t Head and Neckd : John Wiley & Sonsg 32:9, s. 1185-1194q 32:9<1185-1194x 1043-3074x 1097-0347 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15136 |
| 856 | 4 8 | u https://doi.org/10.1002/hed.21317 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121244547 |
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