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  • Myhre, Peder L.Akershus Univ Hosp, Norway; Univ Oslo, Norway; Brigham and Womens Hosp, MA 02115 USA; Harvard Med Sch, MA USA (author)

Cardiac Troponin T Concentrations, Reversible Myocardial Ischemia, and Indices of Left Ventricular Remodeling in Patients with Suspected Stable Angina Pectoris: a DOPPLER-CIP Substudy

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-09-01
  • AMER ASSOC CLINICAL CHEMISTRY,2018
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:liu-152632
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152632URI
  • https://doi.org/10.1373/clinchem.2018.288894DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Akershus University Hospital; Norwegian Research Council; South-Eastern Regional Health Authority; EU (FP7) framework program; South-Eastern Norway Regional Health Authority; Roche Diagnostics
  • BACKGROUND: Cardiac troponin T concentrations measured with high-sensitivity assays (hs-cTnT) provide important prognostic information for patients with stable coronary artery disease (CAD). However, whether hsc-TnT concentrations mainly reflect left ventricular (LV) remodeling or recurrent myocardial ischemia in this population is not known. METHODS: We measured hs-cTnT concentrations in 619 subjects with suspected stable CAD in a prospectively designed multicenter study. We identified associations with indices of LV remodeling, as assessed by cardiac MRI and echocardiography, and evidence of myocardial ischemia diagnosed by single positron emission computed tomography. RESULTS: Median hs-cTnT concentration was 7.8 ng/L (interquartile range, 4.8 -11.6 ng/L), and 111 patients (18%) had hs-cTnT concentrations above the upper reference limit (amp;gt; 14 ng/L). Patients with hs-cTnT amp;gt; 14 ng/L had increased LV mass (144 +/- 40 g vs 116 +/- 34 g; P amp;lt; 0.001) and volume (179 +/- 80 mL vs 158 +/- 44 mL; P = 0.006), lower LV ejection fraction (LVEF) (59 +/- 14 vs 62 +/- 11; P = 0.006) and global longitudinal strain (14.1 +/- 3.4% vs 16.9 +/- 3.2%; P amp;lt; 0.001), and more reversible perfusion defects (P amp;lt; 0.001) and reversible wall motion abnormalities (P = 0.008). Age (P = 0.009), estimated glomerular filtration rate (P = 0.01), LV mass (P = 0.003), LVEF (P = 0.03), and evidence of reversible myocardial ischemia (P = 0.004 for perfusion defects and P = 0.02 for LV wall motion) were all associated with increasing hs-cTnT concentrations in multivariate analysis. We found analogous results when using the revised US upper reference limit of 19 ng/L. CONCLUSIONS: hs-cTnT concentrations reflect both LV mass and reversible myocardial ischemia in patients with suspected stable CAD. (c) 2018 American Association for Clinical Chemistry

Subject headings and genre

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  • Omland, TorbjornAkershus Univ Hosp, Norway; Univ Oslo, Norway (author)
  • Sarvari, Sebastian I.Univ Oslo, Norway; Univ Oslo, Norway (author)
  • Ukkonen, HeikkiTurku Univ Hosp, Finland (author)
  • Rademakers, FrankUniv Hosp Leuven, Belgium; Katholieke Univ Leuven, Belgium (author)
  • Engvall, JanLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)janen74 (author)
  • Hagve, Tor-ArneAkershus Univ Hosp, Norway; Univ Oslo, Norway (author)
  • Nagel, EikeKings Coll Hosp London, England (author)
  • Sicari, RosaCNR, Italy (author)
  • Zamorano, Jose L.Hosp Univ Ramon and Cajal, Spain (author)
  • Monaghan, MarkKings Coll Hosp London, England (author)
  • Dhooge, JanUniv Hosp Leuven, Belgium; Katholieke Univ Leuven, Belgium (author)
  • Edvardsen, ThorUniv Oslo, Norway (author)
  • Rosjo, HelgeAkershus Univ Hosp, Norway; Univ Oslo, Norway (author)
  • Akershus Univ Hosp, Norway; Univ Oslo, Norway; Brigham and Womens Hosp, MA 02115 USA; Harvard Med Sch, MA USAAkershus Univ Hosp, Norway; Univ Oslo, Norway (creator_code:org_t)

Related titles

  • In:Clinical Chemistry: AMER ASSOC CLINICAL CHEMISTRY64:9, s. 1370-13790009-91471530-8561

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