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Sökning: onr:"swepub:oai:DiVA.org:liu-152632" > Cardiac Troponin T ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004919naa a2200469 4500
001oai:DiVA.org:liu-152632
003SwePub
008181109s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1526322 URI
0247 a https://doi.org/10.1373/clinchem.2018.2888942 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Myhre, Peder L.u Akershus Univ Hosp, Norway; Univ Oslo, Norway; Brigham and Womens Hosp, MA 02115 USA; Harvard Med Sch, MA USA4 aut
2451 0a Cardiac Troponin T Concentrations, Reversible Myocardial Ischemia, and Indices of Left Ventricular Remodeling in Patients with Suspected Stable Angina Pectoris: a DOPPLER-CIP Substudy
264 c 2018-09-01
264 1b AMER ASSOC CLINICAL CHEMISTRY,c 2018
338 a print2 rdacarrier
500 a Funding Agencies|Akershus University Hospital; Norwegian Research Council; South-Eastern Regional Health Authority; EU (FP7) framework program; South-Eastern Norway Regional Health Authority; Roche Diagnostics
520 a BACKGROUND: Cardiac troponin T concentrations measured with high-sensitivity assays (hs-cTnT) provide important prognostic information for patients with stable coronary artery disease (CAD). However, whether hsc-TnT concentrations mainly reflect left ventricular (LV) remodeling or recurrent myocardial ischemia in this population is not known. METHODS: We measured hs-cTnT concentrations in 619 subjects with suspected stable CAD in a prospectively designed multicenter study. We identified associations with indices of LV remodeling, as assessed by cardiac MRI and echocardiography, and evidence of myocardial ischemia diagnosed by single positron emission computed tomography. RESULTS: Median hs-cTnT concentration was 7.8 ng/L (interquartile range, 4.8 -11.6 ng/L), and 111 patients (18%) had hs-cTnT concentrations above the upper reference limit (amp;gt; 14 ng/L). Patients with hs-cTnT amp;gt; 14 ng/L had increased LV mass (144 +/- 40 g vs 116 +/- 34 g; P amp;lt; 0.001) and volume (179 +/- 80 mL vs 158 +/- 44 mL; P = 0.006), lower LV ejection fraction (LVEF) (59 +/- 14 vs 62 +/- 11; P = 0.006) and global longitudinal strain (14.1 +/- 3.4% vs 16.9 +/- 3.2%; P amp;lt; 0.001), and more reversible perfusion defects (P amp;lt; 0.001) and reversible wall motion abnormalities (P = 0.008). Age (P = 0.009), estimated glomerular filtration rate (P = 0.01), LV mass (P = 0.003), LVEF (P = 0.03), and evidence of reversible myocardial ischemia (P = 0.004 for perfusion defects and P = 0.02 for LV wall motion) were all associated with increasing hs-cTnT concentrations in multivariate analysis. We found analogous results when using the revised US upper reference limit of 19 ng/L. CONCLUSIONS: hs-cTnT concentrations reflect both LV mass and reversible myocardial ischemia in patients with suspected stable CAD. (c) 2018 American Association for Clinical Chemistry
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Omland, Torbjornu Akershus Univ Hosp, Norway; Univ Oslo, Norway4 aut
7001 a Sarvari, Sebastian I.u Univ Oslo, Norway; Univ Oslo, Norway4 aut
7001 a Ukkonen, Heikkiu Turku Univ Hosp, Finland4 aut
7001 a Rademakers, Franku Univ Hosp Leuven, Belgium; Katholieke Univ Leuven, Belgium4 aut
7001 a Engvall, Janu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US4 aut0 (Swepub:liu)janen74
7001 a Hagve, Tor-Arneu Akershus Univ Hosp, Norway; Univ Oslo, Norway4 aut
7001 a Nagel, Eikeu Kings Coll Hosp London, England4 aut
7001 a Sicari, Rosau CNR, Italy4 aut
7001 a Zamorano, Jose L.u Hosp Univ Ramon and Cajal, Spain4 aut
7001 a Monaghan, Marku Kings Coll Hosp London, England4 aut
7001 a Dhooge, Janu Univ Hosp Leuven, Belgium; Katholieke Univ Leuven, Belgium4 aut
7001 a Edvardsen, Thoru Univ Oslo, Norway4 aut
7001 a Rosjo, Helgeu Akershus Univ Hosp, Norway; Univ Oslo, Norway4 aut
7102 a Akershus Univ Hosp, Norway; Univ Oslo, Norway; Brigham and Womens Hosp, MA 02115 USA; Harvard Med Sch, MA USAb Akershus Univ Hosp, Norway; Univ Oslo, Norway4 org
7730 t Clinical Chemistryd : AMER ASSOC CLINICAL CHEMISTRYg 64:9, s. 1370-1379q 64:9<1370-1379x 0009-9147x 1530-8561
8564 u https://academic.oup.com/clinchem/article-pdf/64/9/1370/32642963/clinchem1370.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152632
8564 8u https://doi.org/10.1373/clinchem.2018.288894

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