Sökning: onr:"swepub:oai:DiVA.org:liu-162596" > Apolipoprotein E ge...
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000 | 07629naa a2200805 4500 | |
001 | oai:DiVA.org:liu-162596 | |
003 | SwePub | |
008 | 191210s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:138698880 | |
009 | oai:lup.lub.lu.se:d45e54a9-1660-4eed-8821-f5b4ff7808df | |
009 | oai:DiVA.org:uu-361543 | |
009 | oai:gup.ub.gu.se/265762 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1625962 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2018.02.0032 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1386988802 URI |
024 | 7 | a https://lup.lub.lu.se/record/d45e54a9-1660-4eed-8821-f5b4ff7808df2 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3615432 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2657622 URI |
040 | a (SwePub)liud (SwePub)kid (SwePub)lud (SwePub)uud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Skillbäck, Tobiasu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xskito |
245 | 1 0 | a Apolipoprotein E genotypes and longevity across dementia disorders |
264 | c 2018-03-13 | |
264 | 1 | b Elsevier,c 2018 |
338 | a print2 rdacarrier | |
520 | a INTRODUCTION: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.METHODS: We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.RESULTS: The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.DISCUSSION: The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Apolipoprotein E | |
653 | a Creutzfeldt-Jakob disease | |
653 | a Dementia with Lewy bodies | |
653 | a Frontotemporal dementia | |
653 | a Parkinson's disease dementia | |
653 | a Vascular dementia | |
653 | a Alzheimer's disease | |
653 | a Apolipoprotein E | |
653 | a Creutzfeldt-Jakob disease | |
653 | a Dementia with Lewy bodies | |
653 | a Frontotemporal dementia | |
653 | a Parkinson's disease dementia | |
653 | a Vascular dementia | |
700 | 1 | a Lautner, Ronaldu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlauro |
700 | 1 | a Mattsson, Niklasu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Malmö, Sweden; Skåne University Hospital, Lund, Sweden,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmö, Sweden; Skåne Univ Hosp, Dept Neurol, Lund, Sweden4 aut0 (Swepub:lu)med-nmn |
700 | 1 | a Schott, Jonathan Mu Dementia Research Centre, UCL Institute of Neurology, London, UK,University College London,UCL Inst Neurol, Dementia Res Ctr, London, England4 aut |
700 | 1 | a Skoog, Ingmaru Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden,Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Mölndal, Sweden4 aut |
700 | 1 | a Nägga, Katarinau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmö, Sweden,Lund University, Malmö, Sweden4 aut0 (Swepub:lu)med-kng |
700 | 1 | a Kilander, Lenau Uppsala universitet,Uppsala University,Geriatrik,Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)lekil226 |
700 | 1 | a Wimo, Andersu Uppsala universitet,Uppsala University,Karolinska Institute,Karolinska Institutet,Centrum för klinisk forskning, Gävleborg,Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden,Karolinska Institutet, Huddinge, Sweden; Uppsala University/County Council of Gävleborg, Gävle, Sweden4 aut |
700 | 1 | a Winblad, Bengtu Karolinska Institute,Karolinska Institutet,Karolinska Institutet, Huddinge, Sweden; Karolinska University Hospital, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden; Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden4 aut |
700 | 1 | a Eriksdotter, Mariau Karolinska Institute,Karolinska Institutet,Karolinska Institutet, Huddinge, Sweden; Karolinska University Hospital, Huddinge, Sweden,Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden; Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden4 aut |
700 | 1 | a Blennow, Kaju Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henriku Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & Dementiad : Elsevierg 14:7, s. 895-901q 14:7<895-901x 1552-5260x 1552-5279 |
856 | 4 | u https://discovery.ucl.ac.uk/10047022/1/Schott_Apolipoprotein%20E%20genotypes%20and%20longevity%20across%20dementia%20disorders.pdf |
856 | 4 | u http://dx.doi.org/10.1016/j.jalz.2018.02.003y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-162596 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2018.02.003 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138698880 |
856 | 4 8 | u https://lup.lub.lu.se/record/d45e54a9-1660-4eed-8821-f5b4ff7808df |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361543 |
856 | 4 8 | u https://gup.ub.gu.se/publication/265762 |
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