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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03760naa a2200421 4500 | |
| 001 | oai:DiVA.org:liu-16735 | |
| 003 | SwePub | |
| 008 | 090213s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167352 URI |
| 024 | 7 | a https://doi.org/10.3132/dvdr.2009.0052 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bjarnegård, Niclasu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet4 aut0 (Swepub:liu)nicbj30 |
| 245 | 1 0 | a Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus |
| 264 | c 2009-01-01 | |
| 264 | 1 | b SAGE Publications,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a Observations of increased stiffness in the elastic aorta in women with diabetes, but not men, emphasise the need for further analysis regarding early abnormalities in arterial wall properties of women with type 1 diabetes mellitus (DM).Ultrasound was used to study the wall properties of the distal brachial artery (BA) in 37 type 1 diabetic women (aged 22-45 years) without evident complications and in 53 controls (C). Blood samples were drawn for later analysis.Flow-mediated dilatation (FMD) was slightly lower in DM than C, 8.1 +/- 4.3% vs. 10.3 +/- 4.9% (p<0.05), and nitrate-mediated dilatation (NMD) was markedly lower, 21.7 +/- 6.6% vs. 31.4 +/- 5.7% (p<0.001). Lumen diameter, intima-media thickness and distensibility were similar in DM and C. Insulin-like growth factor (IGF-1) was lower in DM than C, 231 +/- 65 vs. 349 +/- 68 ng/ml (p<0.001). Glycosylated haemoglobin (HbA(1C)) and matrix metalloproteinase (MMP-9) were independent predictors of the reduced NMD in the DM.Brachial artery responsiveness to an exogenous donor of nitric oxide (NO) was markedly reduced in type 1 diabetic women despite only limited reduction in endothelium-dependent dilatation. The negative association between NMD and HbA(1C) suggests that long-term hyperglycaemia impairs vascular smooth muscle cell function in DM. | |
| 653 | a brachial artery | |
| 653 | a hyperglycaemia | |
| 653 | a type 1 diabetes | |
| 653 | a ultrasound | |
| 653 | a vasodilatation | |
| 653 | a women | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Arnqvist, Hansu Linköpings universitet,Cellbiologi,Hälsouniversitetet,Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Endocrinology and Gastroenterology; Närsjukvården i centrala Östergötland; Endokrin- och magtarmmedicinska kliniken4 aut0 (Swepub:liu)hanar64 |
| 700 | 1 | a Lindström, Torbjörnu Linköpings universitet,Internmedicin,Hälsouniversitetet,Landstinget i Östergötland; Local Health Care Services in Central Östergötland; Department of Endocrinology and Gastroenterology; Närsjukvården i centrala Östergötland; Endokrin- och magtarmmedicinska kliniken4 aut0 (Swepub:liu)torli22 |
| 700 | 1 | a Jonasson, Lenau Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken4 aut0 (Swepub:liu)lenjo59 |
| 700 | 1 | a Jonsson, Andersu Jönköping Hospital4 aut |
| 700 | 1 | a Länne, Tosteu Östergötlands Läns Landsting,Linköpings universitet,Fysiologi,Hälsouniversitetet,Thorax-kärlkliniken4 aut0 (Swepub:liu)tosla34 |
| 710 | 2 | a Linköpings universitetb Avdelningen för kardiovaskulär medicin4 org |
| 773 | 0 | t DIABETES and VASCULAR DISEASE RESEARCHd : SAGE Publicationsg 6:1, s. 25-31q 6:1<25-31x 1479-1641x 1752-8984 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16735 |
| 856 | 4 8 | u https://doi.org/10.3132/dvdr.2009.005 |
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