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Extravascular lung ...
Extravascular lung water levels are associated with mortality : a systematic review and meta-analysis
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- Gavelli, Francesco (author)
- DMU CORREVE, France; Univ Piemonte Orientale, Italy
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- Shi, Rui (author)
- DMU CORREVE, France; Univ Paris Saclay, France
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- Teboul, Jean-Louis (author)
- DMU CORREVE, France; Univ Paris Saclay, France
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- Azzolina, Danila (author)
- Univ Ferrara, Italy
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- Mercado, Pablo (author)
- Univ Desarrollo, Chile
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- Jozwiak, Mathieu (author)
- Ctr Hosp Univ Archet 1, France; Univ Cote Azur, France
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- Chew, Michelle (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Huber, Wolfgang (author)
- Tech Univ Munich, Germany
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- Kirov, Mikhail Y. (author)
- Northern State Med Univ, Russia
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- Kuzkov, Vsevolod V. (author)
- Northern State Med Univ, Russia
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- Lahmer, Tobias (author)
- Tech Univ Munich, Germany
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- Malbrain, Manu L. N. G. (author)
- Med Univ Lublin, Poland; Int Fluid Acad, Belgium
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- Mallat, Jihad (author)
- Schaffner Hosp, France; Cleveland Clin Abu Dhabi, U Arab Emirates
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- Sakka, Samir G. (author)
- Johannes Gutenberg Univ Mainz, Germany
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- Tagami, Takashi (author)
- Nippon Med Sch, Japan
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- Pham, Tai (author)
- DMU CORREVE, France; Univ Paris Saclay, France
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- Monnet, Xavier (author)
- DMU CORREVE, France; Univ Paris Saclay, France
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(creator_code:org_t)
- 2022-07-06
- 2022
- English.
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In: Critical Care. - : BMC. - 1364-8535 .- 1466-609X. ; 26:1
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background The prognostic value of extravascular lung water (EVLW) measured by transpulmonary thermodilution (TPTD) in critically ill patients is debated. We performed a systematic review and meta-analysis of studies assessing the effects of TPTD-estimated EVLW on mortality in critically ill patients. Methods Cohort studies published in English from Embase, MEDLINE, and the Cochrane Database of Systematic Reviews from 1960 to 1 June 2021 were systematically searched. From eligible studies, the values of the odds ratio (OR) of EVLW as a risk factor for mortality, and the value of EVLW in survivors and non-survivors were extracted. Pooled OR were calculated from available studies. Mean differences and standard deviation of the EVLW between survivors and non-survivors were calculated. A random effects model was computed on the weighted mean differences across the two groups to estimate the pooled size effect. Subgroup analyses were performed to explore the possible sources of heterogeneity. Results Of the 18 studies included (1296 patients), OR could be extracted from 11 studies including 905 patients (464 survivors vs. 441 non-survivors), and 17 studies reported EVLW values of survivors and non-survivors, including 1246 patients (680 survivors vs. 566 non-survivors). The pooled OR of EVLW for mortality from eleven studies was 1.69 (95% confidence interval (CI) [1.22; 2.34], p < 0.0015). EVLW was significantly lower in survivors than non-survivors, with a mean difference of -4.97 mL/kg (95% CI [-6.54; -3.41], p < 0.001). The results regarding OR and mean differences were consistent in subgroup analyses. Conclusions The value of EVLW measured by TPTD is associated with mortality in critically ill patients and is significantly higher in non-survivors than in survivors. This finding may also be interpreted as an indirect confirmation of the reliability of TPTD for estimating EVLW at the bedside. Nevertheless, our results should be considered cautiously due to the high risk of bias of many studies included in the meta-analysis and the low rating of certainty of evidence. Trial registration the study protocol was prospectively registered on PROSPERO: CRD42019126985.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Lung edema; Transpulmonary thermodilution; Hemodynamic monitoring; Critically ill patients
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Gavelli, Frances ...
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Shi, Rui
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Teboul, Jean-Lou ...
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Azzolina, Danila
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Mercado, Pablo
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Jozwiak, Mathieu
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show more...
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Chew, Michelle
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Huber, Wolfgang
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Kirov, Mikhail Y ...
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Kuzkov, Vsevolod ...
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Lahmer, Tobias
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Malbrain, Manu L ...
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Mallat, Jihad
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Sakka, Samir G.
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Tagami, Takashi
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Pham, Tai
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Monnet, Xavier
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Critical Care
- By the university
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Linköping University