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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00014840naa a2200805 4500
001oai:DiVA.org:liu-189357
003SwePub
008221018s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1893572 URI
0247 a https://doi.org/10.1016/j.schres.2022.09.0092 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Smart, Sophie E.u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 aut
2451 0a Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium
264 1b Elsevier,c 2022
338 a electronic2 rdacarrier
500 a Funding: Medical Research Council [MR/L011794/1]; National Institute for Health Research Biomedical Research Centre at South London and Maudsley National Health Service Foundation Trust; Kings College London; Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South London at Kings College Hospital National Health Service Foundation Trust; UK Medical Research Council [G0500817]; Research and Development Office of Northern Ireland; European Communitys Seventh Framework Program [HEALTH-F2-2010-241909]; UK National Institute of Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health, South London and Maudsley NHS Mental Health Foundation Trust (SLaM); Institute of Psychiatry, Psychology, and Neuroscience at Kings College London; Psychiatry Research Trust; Maudsley Charity Research Fund; European Community [HEALTH-F2-2010-241909, HEALTH-F2-2009-241909]; Swiss National Science Foundation [320030_135736/1, 320030120686, 324730-144064, 320030-173211, 171804]; National Center of Competence in Research (NCCR) "SYNAPSY - The Synaptic Bases of Mental Diseases" from the Swiss National Science Foundation [51AU40_125759]; Fondation Alamaya; Research Council of Norway [223273/F50, 300309, 283798]; South-Eastern Norway Regional Health Authority [2006233, 2006258, 2011085, 2014102, 2015088, 2017-112]; Ministry of Health of the Czech Republic [NU20-04-00393]; Instituto de Salud Carlos III [FIS 00/3095, PI020499, PI050427, PI060507]; Plan Nacional de Drogas Research Grant [2005-Orden sco/3246/2004]; SENY Fundatio Research Grant [CI 2005-0308007]; Fundacion Marques de Valdecilla [A/02/07, API07/011]; MINECO [SAF2016-76046-R, SAF2013-46292-R]; FEDER [SAF2016-76046-R, SAF2013-46292-R]; Wellcome Trust [042025, 052247, 064607]
520 a IntroductionOur aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR.MethodsWe combined data from ten prospective, first-episode psychosis cohorts from across Europe and categorised patients as TR or non-treatment resistant (NTR) after a mean follow up of 4.18 years (s.d. = 3.20) for secondary data analysis. We identified a list of potential predictors from clinical and demographic data recorded at first-episode. These potential predictors were entered in two models: a multivariable logistic regression to identify which were independently associated with TR and a penalised logistic regression, which performed variable selection, to produce a parsimonious prediction model. This model was internally validated using a 5-fold, 50-repeat cross-validation optimism-correction.ResultsOur sample consisted of N = 2216 participants of which 385 (17 %) developed TR. Younger age of psychosis onset and fewer years in education were independently associated with increased odds of developing TR. The prediction model selected 7 out of 17 variables that, when combined, could quantify the risk of being TR better than chance. These included age of onset, years in education, gender, BMI, relationship status, alcohol use, and positive symptoms. The optimism-corrected area under the curve was 0.59 (accuracy = 64 %, sensitivity = 48 %, and specificity = 76 %).ImplicationsOur findings show that treatment resistance can be predicted, at first-episode of psychosis. Pending a model update and external validation, we demonstrate the potential value of prediction models for TR.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a Treatment resistant schizophrenia; First episode psychosis; Prospective longitudinal cohort; Prediction modelling; Stratification; Machine learning
7001 a Agbedjro, Deborahu Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 aut
7001 a Pardiñas, Antonio F.u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK4 aut
7001 a Ajnakina, Olesyau Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, UK4 aut
7001 a Alameda, Luisu Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Centro de Investigacion en Red Salud Mental (CIBERSAM), Sevilla, Spain; Department of Psychiatry, Hospital Universitario Virgen del Rocio, IBiS, Universidad de Sevilla, Spain; TIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Andreassen, Ole A.u Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway4 aut
7001 a Barnes, Thomas R.E.u Division of Psychiatry, Imperial College London, UK4 aut
7001 a Berardi, Domenicou Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy4 aut
7001 a Camporesi, Sarau TIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Cleusix, Martineu Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Conus, Philippeu TIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Crespo-Facorro, Benedictou Centro de Investigacion en Red Salud Mental (CIBERSAM), Sevilla, Spain; Department of Psychiatry, Hospital Universitario Virgen del Rocio, IBiS, Universidad de Sevilla, Spain4 aut
7001 a D'Andrea, Giuseppeu Department of Biomedical and Neuro-motor Sciences, Psychiatry Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy4 aut
7001 a Demjaha, Arsimeu Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 aut
7001 a Di Forti, Martau Social Genetics and Developmental Psychiatry, Institute of Psychiatry, Psychology & Neuroscience; , King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK4 aut
7001 a Do, Kimu Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Doody, Gillianu Department of Medical Education, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK4 aut
7001 a Eap, Chin B.u Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland; Center for Research and Innovation in Clinical Pharmaceutical Sciences, University of Lausanne, Switzerland; Institute of Pharmaceutical Sciences of Western, Switzerland, University of Geneva, University of Lausanne4 aut
7001 a Ferchiou, Azizu Univ Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, FHU ADAPT, Creteil, France4 aut
7001 a Guidi, Lorenzou Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum – University of Bologna, Bologna, Italy4 aut
7001 a Homman, Linau Linköpings universitet,Avdelningen för funktionsnedsättning och samhälle,Filosofiska fakulteten4 aut0 (Swepub:liu)homli50
7001 a Jenni, Raoulu Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Joyce, Eileenu Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK4 aut
7001 a Kassoumeri, Laurau Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 aut
7001 a Lastrina, Ornellau Department of Medical and Surgical Sciences, Bologna Transcultural Psychosomatic Team (BoTPT), Alma Mater Studiorum – University of Bologna, Bologna, Italy4 aut
7001 a Melle, Ingridu Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway4 aut
7001 a Morgan, Craigu Health Service and Population Research, King's College London, London, UK; Centre for Society and Mental Health, King's College London, London, UK4 aut
7001 a O'Neill, Francis A.u Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast, Belfast, UK4 aut
7001 a Pignon, Baptisteu Univ Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, FHU ADAPT, Creteil, France4 aut
7001 a Restellini, Romeou TIPP (Treatment and Early Intervention in Psychosis Program), Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland4 aut
7001 a Richard, Jean-Romainu Univ Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France4 aut
7001 a Simonsen, Carmenu Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Early Intervention in Psychosis Advisory Unit for South East Norway (TIPS Sør-Øst), Division of Mental Health and Addiction, Oslo University Hospital, Norway4 aut
7001 a Španiel, Filipu Department of Applied Neuroscience and Neuroimaging, National Institute of Mental Health, Klecany, Czechia; Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Prague, Czechia4 aut
7001 a Szöke, Andreiu Univ Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, FHU ADAPT, Creteil, France4 aut
7001 a Tarricone, Ilariau Health Service and Population Research, King's College London, London, UK4 aut
7001 a Tortelli, Andreau Univ Paris Est Creteil, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, Creteil, France; Groupe Hospitalier Universitaire Psychiatrie Neurosciences Paris, Pôle Psychiatrie Précarité, Paris, France4 aut
7001 a Üçok, Alpu Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey4 aut
7001 a Vázquez-Bourgon, Javieru Centro de Investigacion en Red Salud Mental (CIBERSAM), Sevilla, Spain; Department of Psychiatry, University Hospital Marques de Valdecilla - Instituto de Investigación Marques de Valdecilla (IDIVAL), Santander, Spain; Department of Medicine and Psychiatry, School of Medicine, University of Cantabria, Santander, Spain4 aut
7001 a Murray, Robin M.u Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 aut
7001 a Walters, James T.R.u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK4 aut
7001 a Stahl, Danielu Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 aut
7001 a MacCabe, James H.u Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK4 aut
7102 a MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKb Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK4 org
7730 t Schizophrenia Researchd : Elsevierg 250q 250x 0920-9964x 1573-2509
8564 u https://liu.diva-portal.org/smash/get/diva2:1704581/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189357
8564 8u https://doi.org/10.1016/j.schres.2022.09.009

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