Sökning: onr:"swepub:oai:DiVA.org:liu-20816" > Incorporation of My...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04241naa a2200457 4500 | |
001 | oai:DiVA.org:liu-20816 | |
003 | SwePub | |
008 | 090922s2008 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-41300 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-208162 URI |
024 | 7 | a https://doi.org/10.1128/IAI.01549-072 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-413002 URI |
040 | a (SwePub)liud (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Welin, Amandau Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping4 aut0 (Swepub:liu)amawe34 |
245 | 1 0 | a Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block. |
264 | 1 | a Washington DC, USA :b American society for microbiology,c 2008 |
338 | a print2 rdacarrier | |
520 | a Lipoarabinomannan (LAM) is one of the key virulence factors for Mycobacterium tuberculosis, the etiological agent of tuberculosis. During uptake of mycobacteria, LAM interacts with the cell membrane of the host macrophage and can be detected throughout the cell upon infection. LAM can inhibit phagosomal maturation as well as induce a proinflammatory response in bystander cells. The aim of this study was to investigate how LAM exerts its action on human macrophages. We show that LAM is incorporated into membrane rafts of the macrophage cell membrane via its glycosylphosphatidylinositol anchor and that incorporation of mannose-capped LAM from M. tuberculosis results in reduced phagosomal maturation. This is dependent on successful insertion of the glycosylphosphatidylinositol anchor. LAM does not, however, induce the phagosomal maturation block through activation of p38 mitogen-activated protein kinase, contradicting some previous suggestions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a Microbiology, immunology, infectious diseases | |
653 | a Mikrobiologi, immunologi, infektionssjukdomar | |
700 | 1 | a Winberg Tinnerfelt, Martinu Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet4 aut0 (Swepub:liu)marwi07 |
700 | 1 | a Abdalla, Hanau Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping4 aut0 (Swepub:liu)hanab12 |
700 | 1 | a Särndahl Lindblom, Evau Örebro universitet,Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Institutionen för hälsovetenskap och medicin,Linköping University, Linköping4 aut0 (Swepub:oru)easl |
700 | 1 | a Rasmusson, Birgittau Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping4 aut0 (Swepub:liu)birra51 |
700 | 1 | a Stendahl, Olleu Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Linköping University, Linköping4 aut0 (Swepub:liu)ollst48 |
700 | 1 | a Lerm, Maria,d 1973-u Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet,Lerm,Linköping University, Linköping4 aut0 (Swepub:liu)marle69 |
700 | 1 | a Winberg, Martin Eu Linköping University, Linköping4 aut |
710 | 2 | a Linköpings universitetb Medicinsk mikrobiologi4 org |
773 | 0 | t Infection and Immunityd Washington DC, USA : American society for microbiologyg 76:7, s. 2882-2887q 76:7<2882-2887x 0019-9567x 1098-5522 |
856 | 4 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43383y Link to Ph.D. Thesis |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20816 |
856 | 4 8 | u https://doi.org/10.1128/IAI.01549-07 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41300 |
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