Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival

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Fältnamn	Indikatorer	Metadata
000		02986naa a2200337 4500
001		oai:DiVA.org:liu-43420
003		SwePub
008		091010s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-434202 URI
024	7	a https://doi.org/10.1002/ijc.235272 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Shabo, Ivan,d 1972-u Linköpings universitet,Kirurgi,Hälsouniversitetet4 aut0 (Swepub:liu)ivash79
245	1 0	a Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
264		c 2008-05-27
264	1	b Wiley,c 2008
338		a print2 rdacarrier
520		a Cells of the monocyte/macrophage lineage are important for tumour cell migration, invasion and metastasis. Fusion between macrophages and cancer cells in animal models in vitro and in vivo causes hybrids with increased metastatic potential. Primary breast cancer cells were characterized for macrophage antigens to test if phenotypic resemblance to macrophages is related to early distant recurrence. Immunostaining for CD163, MAC387 and CD68 was performed in a breast cancer tissue micro array from 127 patients consequently followed up for a median of 13 years. Tumour-associated macrophages expressed all 3 antigens. The breast cancers expressed CD163 to 48%, MAC387 to 14% while CD68 was not expressed. TGF-β staining intensity was positively related to both CD163 and MAC387 expression. Expression of CD163 in the cancer cells was compared to their DNA ploidy, Nottingham Histological Grade, TNM-stage, node state, presence of estrogen receptors and occurrence of distant metastases and survival. Cancers of a more advanced histological grade expressed CD163 to a higher extent. Cells expressing MAC387 were more common in cancers with a high proportion of CD163 positive cells. Multivariate analysis showed that expression of the macrophage antigen CD163 in breast cancer cells has a prognostic impact on the occurrence of distant metastases and reduced patient survival time.
653		a MEDICINE
653		a MEDICIN
700	1	a Stål, Olle,d 1952-u Linköpings universitet,Onkologi,Hälsouniversitetet4 aut0 (Swepub:liu)ollst87
700	1	a Olsson, Hans,d 1963-u Linköpings universitet,Patologi,Hälsouniversitetet4 aut0 (Swepub:liu)hanol61
700	1	a Doré, Siv,d 1955-u Linköpings universitet,Patologi,Hälsouniversitetet4 aut0 (Swepub:liu)sivdo44
700	1	a Svanvik, Joar,d 1942-u Linköpings universitet,Kirurgi,Hälsouniversitetet4 aut0 (Swepub:liu)joasv32
710	2	a Linköpings universitetb Kirurgi4 org
773	0	t International Journal of Cancerd : Wileyg 123:4, s. 780-786q 123:4<780-786x 0020-7136x 1097-0215
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43420
856	4 8	u https://doi.org/10.1002/ijc.23527

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Av författaren/redakt...: Shabo, Ivan, 197 ...; Stål, Olle, 1952 ...; Olsson, Hans, 19 ...; Doré, Siv, 1955-; Svanvik, Joar, 1 ...

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Av lärosätet: Linköpings universitet

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