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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04226naa a2200469 4500 | |
| 001 | oai:DiVA.org:liu-47470 | |
| 003 | SwePub | |
| 008 | 091011s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-474702 URI |
| 024 | 7 | a https://doi.org/10.1096/fj.00-0251com2 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Neuzil, J.u Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany, Institute for Prevention of Cardiovascular Diseases, Pettenkoferstrasse 9, 80336 Munich, Germany4 aut |
| 245 | 1 0 | a Induction of cancer cell apoptosis by a-tocopheryl succinate :b Molecular pathways and structural requirements |
| 264 | c 2001-02 | |
| 264 | 1 | b Wiley,c 2001 |
| 338 | a print2 rdacarrier | |
| 520 | a The vitamin E analog a-tocopheryl succinate (a-TOS) can induce apoptosis. We show that the proapoptotic activity of a-TOS in hematopoietic and cancer cell lines involves inhibition of protein kinase C (PKC), since phorbol myristyl acetate prevented a-TOS-triggered apoptosis. More selective effectors indicated that a-TOS reduced PKCa isotype activity by increasing protein phosphatase 2A (PP2A) activity. The role of PKCa inhibition in a-TOS-induced apoptosis was confirmed using antisense oligonucleotides or PKCa overexpression. Gain- or loss-of-function bcl-2 mutants implied modulation of bcl-2 activity by PKC/PP2A as a mitochondrial target of a-TOS-induced proapoptotic signals. Structural analogs revealed that a-tocopheryl and succinyl moieties are both required for maximizing these effects. In mice with colon cancer xenografts, a-TOS suppressed tumor growth by 80%. This epitomizes cancer cell killing by a pharmacologically relevant compound without known side effects. | |
| 653 | a Colon cancer | |
| 653 | a Programmed cell death | |
| 653 | a Protein kinase C | |
| 653 | a Vitamin E succinate | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Weber, T.u Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany4 aut |
| 700 | 1 | a Schroder, A.u Schröder, A., Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany4 aut |
| 700 | 1 | a Lu, M.u Medical Center North, Vanderbilt University, Nashville, TN, United States4 aut |
| 700 | 1 | a Ostermann, G.u Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany4 aut |
| 700 | 1 | a Gellert, N.u Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany4 aut |
| 700 | 1 | a Mayne, G.C.u Flinders University of South Australia, Adelaide, SA, Australia4 aut |
| 700 | 1 | a Olejnicka, Beatau Linköpings universitet,Hälsouniversitetet,Experimentell patologi4 aut0 (Swepub:liu)beaol03 |
| 700 | 1 | a Negre-Salvayre, A.u Nègre-Salvayre, A., Biochemistry Department, INSERM, Toulouse, France4 aut |
| 700 | 1 | a Sticha, M.u Stícha, M., Faculty of Science, Charles University, Prague, Czech Republic4 aut |
| 700 | 1 | a Coffey, R.J.u Medical Center North, Vanderbilt University, Nashville, TN, United States4 aut |
| 700 | 1 | a Weber, C.u Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany, Institute for Prevention of Cardiovascular Diseases, Pettenkoferstrasse 9, 80336 Munich, Germany4 aut |
| 710 | 2 | a Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany, Institute for Prevention of Cardiovascular Diseases, Pettenkoferstrasse 9, 80336 Munich, Germanyb Institute for Prevention of Cardiovascular Diseases and Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany4 org |
| 773 | 0 | t The FASEB Journald : Wileyg 15:2, s. 403-415q 15:2<403-415x 0892-6638x 1530-6860 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-47470 |
| 856 | 4 8 | u https://doi.org/10.1096/fj.00-0251com |
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