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Sökning: onr:"swepub:oai:DiVA.org:liu-51402" > Early abciximab adm...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003937naa a2200421 4500
001oai:DiVA.org:liu-51402
003SwePub
008091030s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-514022 URI
0247 a https://doi.org/10.1016/j.ahj.2009.08.0082 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rakowski, Tomaszu Jagiellonian University4 aut
2451 0a Early abciximab administration before transfer for primary percutaneous coronary interventions for ST-elevation myocardial infarction reduces 1-year mortality in patients with high-risk profile. Results from EUROTRANSFER Registry
264 1b Elsevier BV,c 2009
338 a print2 rdacarrier
520 a Background There are conflicting data on the clinical benefit from early administration of abciximab from a large randomized trial and a registry. However, both sources suggest that a benefit may depend on the baseline risk profile of the patients. We evaluated the role of early abciximab administration in patients with ST-segment-elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention stratified by the STEMI Thrombolysis In Myocardial Infarction (TIMI) risk score. Methods A total of 1,650 patients were enrolled into the EUROTRANSFER Registry. One thousand eighty-six patients received abciximab (66%). Abciximab was administered early in 727 patients (EA) and late in 359 patients (LA). We used the TIMI risk score for risk stratification. Patients with scores 3 constituted the high-risk group of 616 patients (56.7%), whereas 470 patients formed the low-risk cohort. Factoring in the timing of the abciximab administration resulted in 4 groups of patients who were compared for mortality at 1 year: EA/high-risk (n = 413); LA/high-risk (n = 203); EA/low-risk (n = 3 14); LA/low-risk (n = 156). Baseline difference was accounted for by means of propensity score. Results In high-risk patients, 1-year mortality was significantly lower with early abcximab compared to late administration (8.7% vs 15.8%; odds ratio 0.51, CI 0.31-0.85, P = .01). In multivariable Cox regression analysis, both early abciximab administration and patients risk profile (TIMI score :3) were identified as independent predictors of 1-year mortality. Conclusions Early abciximab administration before transfer for percutaneous coronary intervention in STEMI shows lower mortality at 1-year follow-up. This effect is confined to patients with higher risk profile as defined by TIMI risk score andgt;= 3.
653 a MEDICINE
653 a MEDICIN
7001 a Siudak, Zbigniewu Jagiellonian University4 aut
7001 a Dziewierz, Arturu Jagiellonian University4 aut
7001 a Birkemeyer, Ralfu Schwarzwald Baar Klinikum Villingen Schwenningen4 aut
7001 a Legutko, Jaceku Jagiellonian University4 aut
7001 a Mielecki, Waldemaru Jagiellonian University4 aut
7001 a Depukat, Rafalu Jagiellonian University4 aut
7001 a Janzon, Magnusu Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken4 aut0 (Swepub:liu)magja75
7001 a Stefaniak, Justynau Krakow Cardiovasc Research Institute4 aut
7001 a Zmudka, Krzysztofu Jagiellonian University4 aut
7001 a Dubiel, Jacek Su Jagiellonian University4 aut
7001 a Partyka, Lukaszu Krakow Cardiovasc Research Institute4 aut
7001 a Dudek, Dariuszu Jagiellonian University4 aut
7102 a Jagiellonian Universityb Schwarzwald Baar Klinikum Villingen Schwenningen4 org
7730 t AMERICAN HEART JOURNALd : Elsevier BVg 158:4, s. 569-575q 158:4<569-575x 0002-8703
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51402
8564 8u https://doi.org/10.1016/j.ahj.2009.08.008

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