Addition of a macrolide to a beta-lactam in bacteremic pneumococcal pneumonia

(creator_code:org_t)

2006-08-04
2006
English.
In: European Journal of Clinical Microbiology and Infectious Diseases. - : Springer Science Business Media. - 0934-9723 .- 1435-4373. ; 25:8, s. 518-521

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a beta-lactam +/- a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/beta-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age greater than 65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)greater than 8.

By the author/editor: Dwyer, R.; Ortqvist, A.; Aufwerber, E.; Henriques Normar ...; Marrie, T.J.; Mufson, M.A.; show more...; Torres, A.; Woodhead, M.A.; Ålenius, M; Kalin, M.; show less...

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