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Separation of advan...
Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA
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- Norén, Bengt (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Forsgren, Mikael Fredrik (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Radiofysikavdelningen US
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- Dahlqvist Leinhard, Olof (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Radiofysikavdelningen US
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- Dahlström, Nils (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Kihlberg, Johan, 1970- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Romu, Thobias (author)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk informatik,Tekniska högskolan
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- Kechagias, Stergios (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Magtarmmedicinska kliniken
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- Almer, Sven (author)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Magtarmmedicinska kliniken
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- Smedby, Örjan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping
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- Lundberg, Peter, 1958- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Radiofysikavdelningen US,Röntgenkliniken i Linköping
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(creator_code:org_t)
- 2012-07-27
- 2013
- English.
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In: European Radiology. - : Springer. - 0938-7994 .- 1432-1084. ; 23:1, s. 174-181
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- ObjectivesTo apply dynamic contrast-enhanced (DCE) MRI on patients presenting with elevated liver enzymes without clinical signs of hepatic decompensation in order to quantitatively compare the hepatocyte-specific uptake of Gd-EOB-DTPA with histopathological fibrosis stage.MethodsA total of 38 patients were prospectively examined using 1.5-T MRI. Data were acquired from regions of interest in the liver and spleen by using time series of single-breath-hold symmetrically sampled two-point Dixon 3D images (non-enhanced, arterial and venous portal phase; 3, 10, 20 and 30 min) following a bolus injection of Gd-EOB-DTPA (0.025 mmol/kg). The signal intensity (SI) values were reconstructed using a phase-sensitive technique and normalised using multiscale adaptive normalising averaging (MANA). Liver-to-spleen contrast ratios (LSC_N) and the contrast uptake rate (KHep) were calculated. Liver biopsy was performed and classified according to the Batts and Ludwig system.ResultsArea under the receiver-operating characteristic curve (AUROC) values of 0.71, 0.80 and 0.78, respectively, were found for KHep, LSC_N10 and LSC_N20 with regard to severe versus mild fibrosis. Significant group differences were found for KHep (borderline), LSC_N10 and LSC_N20.ConclusionsLiver fibrosis stage strongly influences the hepatocyte-specific uptake of Gd-EOB-DTPA. Potentially the normalisation technique and KHep will reduce patient and system bias, yielding a robust approach to non-invasive liver function determination.
Keyword
- Quantification
- Gd-EOB-DTPA
- Dynamic contrast-enhanced MRI
- Pharmacokinetics
- Liver
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Norén, Bengt
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Forsgren, Mikael ...
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Dahlqvist Leinha ...
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Dahlström, Nils
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Kihlberg, Johan, ...
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Romu, Thobias
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Kechagias, Sterg ...
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Almer, Sven
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Smedby, Örjan
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Lundberg, Peter, ...
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- Articles in the publication
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European Radiolo ...
- By the university
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Linköping University