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Akt2 expression is ...
Akt2 expression is associated with good long-term prognosis in oestrogen receptor positive breast cancer
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- Fohlin, Helena (author)
- Östergötlands Läns Landsting,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Regionalt cancercentrum
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- Perez-Tenorio, Gizeh (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Fornander, Tommy (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Skoog, Lambert (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Nordenskjöld, Bo (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Carstensen, John (author)
- Linköpings universitet,Hälsa och samhälle,Hälsouniversitetet
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- Stål, Olle (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- English.
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In: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 49:6, s. 1196-1204
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Abstract
Subject headings
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- IntroductionAkt is a signalling modulator for many cellular processes, including metabolism, cell proliferation, cell survival and cell growth. Three isoforms of Akt have been identified, but only a few studies have concerned the isoform-specific roles in the prognosis of breast cancer patients. The aim of this study was to investigate the prognostic value of v-akt murine thymoma viral oncogene homologue 1 (Akt1) and v-akt murine thymoma viral oncogene homologue 2 (Akt2) in oestrogen receptor positive (ER+) and oestrogen receptor negative (ER–) breast cancer with long-term follow-up.Material and methodsThe expression of Akt in tumour tissue was analysed with immunohistochemistry in a cohort of 272 postmenopausal patients with stage II breast cancer. The median follow-up time was 19 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox’s proportional hazards model.ResultsThe risk of distant recurrence was reduced for patients with ER+ tumours expressing Akt2 compared to patients with no Akt2 expression (HR = 0.49, 95% CI 0.29–0.82, p = 0.007). When adjusting for important clinical tumour characteristics and treatment, Akt2 was still an independent prognostic factor (HR = 0.38, 95% CI 0.21–0.68, p = 0.001) and the association remained long-term. The prognostic value of Akt2 increased with higher oestrogen receptor levels from no effect among patients with ER– tumours to 68% risk reduction for the group with high ER-levels (P for trend = 0.042). Akt1 showed no significant prognostic information.ConclusionOur results indicate that Akt2 expression is associated with a lower distant recurrence rate for patients with ER+ tumours and that this association remains long-term. The prognostic value of Akt2 increases with higher oestrogen receptor expression, motivating further mechanistic studies on the role of Akt2 in ER+ breast cancer.
Keyword
- Breast cancer
- Akt
- Protein kinase B
- Oestrogen receptor
- Long-term
- Prognostic factor
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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