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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03811naa a2200409 4500 | |
| 001 | oai:DiVA.org:liu-97675 | |
| 003 | SwePub | |
| 008 | 130919s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-976752 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00667912 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhang, Danu Sichuan University, Chengdu, Sichuan Province, China4 aut |
| 245 | 1 0 | a Polymorphisms of Glucose-Regulated Protein 78 and Risk of Colorectal Cancer :b A Case-Control Study in Southwest China |
| 264 | c 2013-06-20 | |
| 264 | 1 | b Public Library of Science,c 2013 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|Outstanding Doctoral Dissertation Foundation of Ministry of Education of China|2007B66| | |
| 520 | a Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism to promote malignant transformation of colorectal cancer (CRC) and protect CRC cells against apoptosis. Recently, the analysis of GRP78 polymorphisms has already determined that GRP78 rs391957 polymorphism could predict clinical outcome in CRC patients. Thus, we tested whether GRP78 polymorphisms are related to the risk of CRC. In this study, we detected two GRP78 polymorphisms (rs391957 (C>T) and rs430397 (G>A)) in 414 CRC cases and 502 hospital-based cancer-free healthy controls in Southwest China using a polymerase chain reaction–restriction fragment length polymorphism technique. Compared with the CC genotype, carriers of CT and TT genotypes of rs391957 polymorphism had higher risks of CRC (odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.06–1.83 for CT genotype and OR = 2.10, 95% CI = 1.06–4.14 for TT genotype, respectively). In CRC cases, the variant T allele was significantly associated with tumor invasion stage (P = 0.030), but not with status of lymph nodes metastasis (P = 0.052). Compared with the GG genotype, carriers of GA and AA genotypes of rs430397 polymorphism had higher risks of CRC (OR = 1.63, 95% CI = 1.23–2.15 for GA genotype and OR = 2.92, 95% CI = 1.23–6.94 for AA genotype, respectively). The rs430397 polymorphism was not associated with the clinicopathological characteristics of CRC. These data provide the first evidence that GRP78 rs391957 and rs430397 polymorphisms could serve as markers to predict the risk of CRC. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Zhou, Binu Sichuan University, Chengdu, Sichuan Province, China4 aut |
| 700 | 1 | a Li, Yuanu Sichuan University, Chengdu, Sichuan Province, China4 aut |
| 700 | 1 | a Wang, Mojinu Sichuan University, Chengdu, Sichuan Province, China4 aut |
| 700 | 1 | a Wang, Cunu Sichuan University, Chengdu, Sichuan Province, China4 aut |
| 700 | 1 | a Zhou, Zongguangu Sichuan University, Chengdu, Sichuan Province, China4 aut |
| 700 | 1 | a Sun, Xiao-Fengu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US4 aut0 (Swepub:liu)xiasu45 |
| 710 | 2 | a Sichuan University, Chengdu, Sichuan Province, Chinab Avdelningen för kliniska vetenskaper4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Scienceg 8:6q 8:6x 1932-6203 |
| 856 | 4 | u https://doi.org/10.1371/journal.pone.0066791y Fulltext |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:649968/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066791&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97675 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0066791 |
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