onr:"swepub:oai:DiVA.org:liu-99417"
Sökning: onr:"swepub:oai:DiVA.org:liu-99417" > Hypoxia in the diab...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04209naa a2200373 4500 | |
| 001 | oai:DiVA.org:liu-99417 | |
| 003 | SwePub | |
| 008 | 131017s2013 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-182297 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-994172 URI |
| 024 | 7 | a https://doi.org/10.1007/978-1-4614-4989-8_262 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1822972 URI |
| 040 | a (SwePub)liud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nordquist, Linau Uppsala universitet,Integrativ Fysiologi,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University4 aut0 (Swepub:uu)linor172 |
| 245 | 1 0 | a Hypoxia in the diabetic kidney is independent of advanced glycation end-products. |
| 264 | c 2012-07-21 | |
| 264 | 1 | a New York, NY :b Kluwer Academic Publishers,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Sustained hyperglycemia is closely associated with increased risk to develop nephropathy. We have previously reported alterations in the intrarenal oxygen metabolism already after the early onset of diabetes. Furthermore, formation of advanced glycation end-products (AGE) is postulated as a major contributor to diabetic nephropathy. We therefore investigated the possible relationship between altered oxygen metabolism and AGE in diabetic kidneys.Normoglycemic and streptozotocin-diabetic rats with and without chronic treatment with aminoguanidine (AGE inhibitor; 600 mg/kg bw/24 h in drinking water) or L-N(6)-(1-Iminoethyl)lysine (L-NIL, iNOS inhibitor, 1 mg/kg bw/24 h in drinking water) were studied 2 weeks after induction of diabetes. Glomerular filtration rate (GFR) was estimated by inulin clearance, oxygen tension (pO(2)) and interstitial pH by microelectrodes and regional renal blood flow (RBF) by laser-Doppler. Histological changes were evaluated on fixed tissue.Glomerular hyperfiltration was unaffected by aminoguanidine, whereas L-NIL normalized GFR in diabetic rats. pO(2) and interstitial pH, but not RBF, were lower in both kidney cortex and medulla compared to control rats, but was unaffected by both chronic treatments. Urinary protein excretion was higher in diabetic rats and unaffected by L-NIL, whereas aminoguanidine paradoxically increased this parameter. Damage scores were similar in all groups.In conclusion, diabetes-induced alterations in intrarenal oxygen metabolism are independent of the AGE pathway, and precede any morphological changes. These findings highlight the early stage of diabetes as being a metabolic disorder also in the kidney. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 700 | 1 | a Liss, Per,d 1960-u Uppsala universitet,Enheten för radiologi,Radiology, Oncology and Radiation Science, Uppsala University4 aut0 (Swepub:uu)perliss |
| 700 | 1 | a Fasching, Angelicau Uppsala universitet,Integrativ Fysiologi,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University4 aut0 (Swepub:uu)afa22979 |
| 700 | 1 | a Hansell, Peteru Uppsala universitet,Integrativ Fysiologi,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University4 aut0 (Swepub:uu)petehans |
| 700 | 1 | a Palm, Fredrik,d 1973-u Uppsala universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University, Biomedical Center,Integrativ Fysiologi4 aut0 (Swepub:uu)fredpalm |
| 710 | 2 | a Uppsala universitetb Integrativ Fysiologi4 org |
| 773 | 0 | t Advances in Experimental Medicine and Biologyd New York, NY : Kluwer Academic Publishersg 765, s. 185-193q 765<185-193x 0065-2598x 2214-8019 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99417 |
| 856 | 4 8 | u https://doi.org/10.1007/978-1-4614-4989-8_26 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182297 |
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