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Sökning: onr:"swepub:oai:DiVA.org:lnu-128696" > Protocol for the de...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006713naa a2200757 4500
001oai:DiVA.org:lnu-128696
003SwePub
008240409s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-1286962 URI
0247 a https://doi.org/10.1136/bmjopen-2024-0841642 DOI
040 a (SwePub)lnu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wilkinson, Jacku University of Manchester, UK4 aut
2451 0a Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
264 1b BMJ Publishing Group Ltd,c 2024
338 a print2 rdacarrier
520 a Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review, it is not usual to consider whether the RCTs contain false data. Studies containing false data therefore go unnoticed and contribute to systematic review conclusions. The INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project will develop a tool to assess the trustworthiness of RCTs in systematic reviews of healthcare-related interventions.Methods and analysis The INSPECT-SR tool will be developed using expert consensus in combination with empirical evidence, over five stages: (1) a survey of experts to assemble a comprehensive list of checks for detecting problematic RCTs, (2) an evaluation of the feasibility and impact of applying the checks to systematic reviews, (3) a Delphi survey to determine which of the checks are supported by expert consensus, culminating in, (4) a consensus meeting to select checks to be included in a draft tool and to determine its format and (5) prospective testing of the draft tool in the production of new health systematic reviews, to allow refinement based on user feedback. We anticipate that the INSPECT-SR tool will help researchers to identify problematic studies and will help patients by protecting them from the influence of false data on their healthcare.Ethics and dissemination The University of Manchester ethics decision tool was used, and this returned the result that ethical approval was not required for this project (30 September 2022), which incorporates secondary research and surveys of professionals about subjects relating to their expertise. Informed consent will be obtained from all survey participants. All results will be published as open-access articles. The final tool will be made freely available.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Psychology
653 a Psykologi
7001 a Heal, Calvinu University of Manchester, UK4 aut
7001 a Antoniou, George Au Manchester University NHS Foundation Trust, UK;University of Manchester, UK4 aut
7001 a Flemyng, Ellau Evidence Production and Methods Directorate Cochrane, UK4 aut
7001 a Alfirevic, Zarkou University of Liverpool, UK4 aut
7001 a Avenell, Alisonu University of Aberdeen, UK4 aut
7001 a Barbour, Ginnyu Medical Journal of Australia, Australia4 aut
7001 a Brown, Nicholas,d 1960-u Linnéuniversitetet,Institutionen för psykologi (PSY)4 aut0 (Swepub:lnu)nibrac
7001 a Carlisle, Johnu Torbay Hospital, UK4 aut
7001 a Clarke, Mikeu Queen's University Belfast, UK4 aut
7001 a Dicker, Patricku Royal College of Surgeons in Ireland, Ireland4 aut
7001 a Dumville, Jo Cu University of Manchester, UK;Manchester Academic Health Science Centre, UK4 aut
7001 a Grey, Andrewu University of Auckland, New Zealand4 aut
7001 a Grohmann, Stephu Evidence Production and Methods Directorate Cochrane, UK4 aut
7001 a Gurrin, Lyleu University of Melbourne, Australia4 aut
7001 a Hayden, Jill Alisonu Dalhousie University, Canada4 aut
7001 a Heathers, Jamesu SafeBeat Rx Inc, USA4 aut
7001 a Hunter, Kylie Elizabethu University of Sydney, Australia4 aut
7001 a Lasserson, Tobyu Evidence Production and Methods Directorate Cochrane, UK4 aut
7001 a Lam, Emilyu Independent Lay Member, UK4 aut
7001 a Lensen, Sarahu University of Melbourne, Australia4 aut
7001 a Li, Tianjingu niversity of Colorado, USA4 aut
7001 a Li, Wentaou Monash University, Australia4 aut
7001 a Loder, Elizabethu BMJ Publishing, UK;Brigham and Women's Hospital, USA4 aut
7001 a Lundh, Andreasu Centre of Evidence-Based Medicine Odense, Denmark;Cochrane, Denmark;University of Southern Denmark, Denmark;Copenhagen University Hospita, Denmark4 aut
7001 a Meyerowitz-Katz, Gideonu University of Wollongong, Australia4 aut
7001 a Mol, Ben Wu Monash University, Australia4 aut
7001 a O'Connell, Neil Eu Brunel University, UK;Brunel University, UK4 aut
7001 a Parker, Lisau University of Sydney, Australia4 aut
7001 a Redman, Barbara Ku New York University Grossman School of Medicine, USA4 aut
7001 a Seidler, Leneu University of Sydney, Australia4 aut
7001 a Sheldrick, Kyle Au University of New South Wales, Australia4 aut
7001 a Sydenham, Emmau Cochrane Central Production Service, UK4 aut
7001 a Torgerson, Davidu University of York, UK4 aut
7001 a van Wely, Madelonu Cochrane Gynaecology and Fertility Satellite and Cochrane Sexually Transmitted Infection Group, Netherlands;Amsterdam University Medical Center, Netherlands4 aut
7001 a Wang, Ruiu Monash University, Australia4 aut
7001 a Bero, Lisau University of Colorado, USA4 aut
7001 a Kirkham, Jamie Ju University of Manchester, UK4 aut
7102 a University of Manchester, UKb Manchester University NHS Foundation Trust, UK;University of Manchester, UK4 org
7730 t BMJ Opend : BMJ Publishing Group Ltdg 14:3q 14:3x 2044-6055
8564 u https://doi.org/10.1136/bmjopen-2024-084164y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-128696
8564 8u https://doi.org/10.1136/bmjopen-2024-084164

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