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- Ahlkvist, LindaLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Lund University, Lund, Sweden (author)
Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- Elsevier,2012
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:mau-14450
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-14450URI
- https://doi.org/10.1016/j.regpep.2012.06.004DOI
- https://lup.lub.lu.se/record/2967611URI
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- Language:English
- Summary in:English
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Notes
- Apart from glucose, proteins and lipids also stimulate incretin and islet hormone secretion. However, the glucoregulatory effect of macronutrients in combination is poorly understood. We therefore developed an oral mixed meal model in mice to 1) explore the glucagon-like peptide-1 (GLP-1) and islet hormone responses to mixed meal versus isocaloric glucose, and 2) characterize the relative contribution of individual macronutrients to these responses. Anesthetized C57BL/6J female mice were orally gavaged with 1) a mixed meal (0.285 kcal; glucose, whey protein and peanut oil; 60/20/20% kcal) versus an isocaloric glucose load (0.285 kcal), and 2) a mixed meal (0.285 kcal) versus glucose, whey protein or peanut oil administered individually in their mixed meal caloric quantity, i.e., 0.171, 0.055 and 0.055 kcal, respectively. Plasma was analyzed for glucose, insulin and intact GLP-1 before and during oral challenges. Plasma glucose was lower after mixed meal versus after isocaloric glucose ingestion. In spite of this, the peak insulin response (P=0.02), the peak intact GLP-1 levels (P=0.006) and the estimated β-cell function (P=0.005) were higher. Furthermore, the peak insulin (P=0.004) and intact GLP-1 (P=0.006) levels were higher after mixed meal ingestion than the sum of responses to individual macronutrients. Compared to glucose alone, we conclude that there is a marked early insulin response to mixed meal ingestion, which emanates from a synergistic, rather than an additive, effect of the individual macronutrients in the mixed meal and is in part likely caused by increased levels of GLP-1.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Macronutrients
- Insulin
- GLP-1
- Incretin
- Mixed meal
- Administration
- Oral
- Animals
- Area Under Curve
- Blood Glucose
- Diet
- Female
- Glucagon-Like Peptide 1
- Glucose
- Glucose Tolerance Test
- Incretins
- Insulin
- Insulin Resistance
- Insulin Secretion
- Islets of Langerhans
- Linear Models
- Mice
- Mice
- Inbred C57BL
- Milk Proteins
- Peanut Oil
- Plant Oils
- Whey Proteins
Added entries (persons, corporate bodies, meetings, titles ...)
- Vikman, JennyLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University, Lund, Sweden(Swepub:lu)mphy-jsa (author)
- Pacini, GMetabolic Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy (author)
- Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Lund University, Lund, Sweden(Swepub:lu)med-bah (author)
- Medicin, LundSektion II (creator_code:org_t)
Related titles
- In:Regulatory Peptides: Elsevier178:1-3, s. 29-350167-01151873-1686
Internet link
- https://lup.lub.lu.se/search/files/1870758/3516953.pdf
- https://portal.research.lu.se/files/1870758/3516953.pdfFULLTEXT
- http://www.ncbi.nlm.nih.gov/pubmed/22750278?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1016/j.regpep.2012.06.004FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-14450
- https://doi.org/10.1016/j.regpep.2012.06.004
- https://lup.lub.lu.se/record/2967611
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